Correlation of maternal serum fetuin/α2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes

L. Kalabay, K. Cseh, Attila Pajor, Éva Baranyi, György M. Csákány, Zsolt Melczer, G. Speer, M. Kovács, György Siller, I. Karádi, G. Winkler

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Abstract

Objective: Human fetuin/α2-HS-glycoprotein (AHSG) is a 49 kDa serum and tissue protein which is a natural inhibitor of insulin receptor signaling. We investigated serum AHSG levels during pregnancy and whether the protein is involved in insulin resistance observed in healthy pregnant women and patients with gestational diabetes. Design: One hundred and four healthy pregnant women and 23 of their neonates, 30 patients with gestational diabetes and their neonates and 30 healthy age-matched non-pregnant females as a control group were investigated in a case-control cross-sectional study. Methods: Serum AHSG was determined by radial immunodiffusion. Results: We observed an increase of serum AHSG concentration in the second and third trimesters. Gestational diabetes patients had significantly higher AHSG levels than healthy pregnant women and non-pregnant controls. There was a highly significant positive correlation between serum AHSG concentration and indirect parameters of insulin resistance, i.e. tumor necrosis factor-α (TNF-α), leptin, C-peptide and C-peptide/blood glucose ratio. There was also a negative correlation between maternal AHSG, TNF-α, leptin levels and head circumference, body length and body weight of newborns. Conclusion: AHSG, TNF-α and leptin may contribute to insulin resistance during normal pregnancy and gestational diabet. AHSG along with these cytokines may also negatively regulate neonatal skeletal development.

Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalEuropean Journal of Endocrinology
Volume147
Issue number2
Publication statusPublished - Aug 2002

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Fetuins
Gestational Diabetes
Insulin Resistance
Glycoproteins
Leptin
Mothers
Newborn Infant
Pregnant Women
Pregnancy
C-Peptide
Serum
Lymphotoxin-beta
Tumor Necrosis Factor-alpha
Pregnancy Proteins
Immunodiffusion
Insulin Receptor
Third Pregnancy Trimester
Second Pregnancy Trimester
Blood Glucose
Blood Proteins

ASJC Scopus subject areas

  • Endocrinology

Cite this

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title = "Correlation of maternal serum fetuin/α2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes",
abstract = "Objective: Human fetuin/α2-HS-glycoprotein (AHSG) is a 49 kDa serum and tissue protein which is a natural inhibitor of insulin receptor signaling. We investigated serum AHSG levels during pregnancy and whether the protein is involved in insulin resistance observed in healthy pregnant women and patients with gestational diabetes. Design: One hundred and four healthy pregnant women and 23 of their neonates, 30 patients with gestational diabetes and their neonates and 30 healthy age-matched non-pregnant females as a control group were investigated in a case-control cross-sectional study. Methods: Serum AHSG was determined by radial immunodiffusion. Results: We observed an increase of serum AHSG concentration in the second and third trimesters. Gestational diabetes patients had significantly higher AHSG levels than healthy pregnant women and non-pregnant controls. There was a highly significant positive correlation between serum AHSG concentration and indirect parameters of insulin resistance, i.e. tumor necrosis factor-α (TNF-α), leptin, C-peptide and C-peptide/blood glucose ratio. There was also a negative correlation between maternal AHSG, TNF-α, leptin levels and head circumference, body length and body weight of newborns. Conclusion: AHSG, TNF-α and leptin may contribute to insulin resistance during normal pregnancy and gestational diabet. AHSG along with these cytokines may also negatively regulate neonatal skeletal development.",
author = "L. Kalabay and K. Cseh and Attila Pajor and {\'E}va Baranyi and Cs{\'a}k{\'a}ny, {Gy{\"o}rgy M.} and Zsolt Melczer and G. Speer and M. Kov{\'a}cs and Gy{\"o}rgy Siller and I. Kar{\'a}di and G. Winkler",
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T1 - Correlation of maternal serum fetuin/α2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes

AU - Kalabay, L.

AU - Cseh, K.

AU - Pajor, Attila

AU - Baranyi, Éva

AU - Csákány, György M.

AU - Melczer, Zsolt

AU - Speer, G.

AU - Kovács, M.

AU - Siller, György

AU - Karádi, I.

AU - Winkler, G.

PY - 2002/8

Y1 - 2002/8

N2 - Objective: Human fetuin/α2-HS-glycoprotein (AHSG) is a 49 kDa serum and tissue protein which is a natural inhibitor of insulin receptor signaling. We investigated serum AHSG levels during pregnancy and whether the protein is involved in insulin resistance observed in healthy pregnant women and patients with gestational diabetes. Design: One hundred and four healthy pregnant women and 23 of their neonates, 30 patients with gestational diabetes and their neonates and 30 healthy age-matched non-pregnant females as a control group were investigated in a case-control cross-sectional study. Methods: Serum AHSG was determined by radial immunodiffusion. Results: We observed an increase of serum AHSG concentration in the second and third trimesters. Gestational diabetes patients had significantly higher AHSG levels than healthy pregnant women and non-pregnant controls. There was a highly significant positive correlation between serum AHSG concentration and indirect parameters of insulin resistance, i.e. tumor necrosis factor-α (TNF-α), leptin, C-peptide and C-peptide/blood glucose ratio. There was also a negative correlation between maternal AHSG, TNF-α, leptin levels and head circumference, body length and body weight of newborns. Conclusion: AHSG, TNF-α and leptin may contribute to insulin resistance during normal pregnancy and gestational diabet. AHSG along with these cytokines may also negatively regulate neonatal skeletal development.

AB - Objective: Human fetuin/α2-HS-glycoprotein (AHSG) is a 49 kDa serum and tissue protein which is a natural inhibitor of insulin receptor signaling. We investigated serum AHSG levels during pregnancy and whether the protein is involved in insulin resistance observed in healthy pregnant women and patients with gestational diabetes. Design: One hundred and four healthy pregnant women and 23 of their neonates, 30 patients with gestational diabetes and their neonates and 30 healthy age-matched non-pregnant females as a control group were investigated in a case-control cross-sectional study. Methods: Serum AHSG was determined by radial immunodiffusion. Results: We observed an increase of serum AHSG concentration in the second and third trimesters. Gestational diabetes patients had significantly higher AHSG levels than healthy pregnant women and non-pregnant controls. There was a highly significant positive correlation between serum AHSG concentration and indirect parameters of insulin resistance, i.e. tumor necrosis factor-α (TNF-α), leptin, C-peptide and C-peptide/blood glucose ratio. There was also a negative correlation between maternal AHSG, TNF-α, leptin levels and head circumference, body length and body weight of newborns. Conclusion: AHSG, TNF-α and leptin may contribute to insulin resistance during normal pregnancy and gestational diabet. AHSG along with these cytokines may also negatively regulate neonatal skeletal development.

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