Adatok a HLA antigének és az idiopathiás haemochromatosis hazai kapcsolatához.

Translated title of the contribution: Correlation of HLA antigens and idiopathic hemochromatosis in Hungary

E. Czink, E. Gyódi, K. Német, Z. Hollán

Research output: Contribution to journalArticle

Abstract

The aim of our present work was to collect data on HLA distribution in patients with idiopathic haemochromatosis in Hungary. Ten unrelated patients with idiopathic haemochromatosis (6 men, 4 women) were studied. Idiopathic haemochromatosis was diagnosed on clinical, biochemical and histological grounds. HLA typing was performed in 10 probands and in all of their first degree relatives available (24) through 7 pedigree studies. HLA A3 was present in 6 of 10 probands [6/10 vs. 18.8% in the group of healthy blood donors (No 53) and 22.4% in Hungarian population (No 1910]. HLA B7 was present in 4 of 10 probands (40% vs. 11.3% and 14.6%). A3B7 antigen association has been found in 4 of 10 patients. A3B7 and A2B38 haplotypes were present twice in 4 of 7 genotyped probands. Pedigree studies revealed one nonaffected homozygote, 17 heterozygotes and 6 non carriers. Extended family and population studies are necessary to establish the gene frequency in Hungary and the probability of the involved haplotypes other than A3B7.

Original languageHungarian
Pages (from-to)409-410, 413
JournalOrvosi Hetilap
Volume132
Issue number8
Publication statusPublished - Feb 24 1991

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Hemochromatosis
Hungary
HLA Antigens
Pedigree
Haplotypes
HLA-A3 Antigen
HLA-B7 Antigen
Histocompatibility Testing
Homozygote
Heterozygote
Blood Donors
Gene Frequency
Population
Antigens

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Adatok a HLA antigének és az idiopathiás haemochromatosis hazai kapcsolatához. / Czink, E.; Gyódi, E.; Német, K.; Hollán, Z.

In: Orvosi Hetilap, Vol. 132, No. 8, 24.02.1991, p. 409-410, 413.

Research output: Contribution to journalArticle

Czink, E, Gyódi, E, Német, K & Hollán, Z 1991, 'Adatok a HLA antigének és az idiopathiás haemochromatosis hazai kapcsolatához.', Orvosi Hetilap, vol. 132, no. 8, pp. 409-410, 413.
Czink, E. ; Gyódi, E. ; Német, K. ; Hollán, Z. / Adatok a HLA antigének és az idiopathiás haemochromatosis hazai kapcsolatához. In: Orvosi Hetilap. 1991 ; Vol. 132, No. 8. pp. 409-410, 413.
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