Correlation between the SOD-like activity of hexacoordinate iron(II) complexes and their Fe3+/Fe2+ redox potentials

Balázs Kripli, Gábor Baráth, E. Balogh-Hergovich, Michel Giorgi, A. Jalila Simaan, L. Párkányí, J. Pap, J. Kaizer, G. Speier

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Hexacoordinate, high-spin iron(II) complexes with different isoindoline-derivative ligands have been prepared and characterized. The Fe 3+/Fe2+ redox transition is reversible in each case, but the E1/2 values vary in a ~ 400 mV range depending on the ligand. SOD-like activity of the complexes was determined by indirect methods with cytochrome c, and nitroblue tetrazolium indicator at pH 7.6. The measured activities correlate with the redox potentials for the Fe3+/Fe 2+ couples. The results indicate that the superoxide dismutation takes place via an inner-sphere mechanism at the iron site.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalInorganic Chemistry Communications
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2011

Fingerprint

Iron
Ligands
Nitroblue Tetrazolium
iron
ligands
inorganic peroxides
cytochromes
Cytochromes c
Superoxides
Derivatives
Proteins
Oxidation-Reduction

Keywords

  • Iron
  • Isoindoline ligand
  • Redox chemistry
  • SOD mimics

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Correlation between the SOD-like activity of hexacoordinate iron(II) complexes and their Fe3+/Fe2+ redox potentials. / Kripli, Balázs; Baráth, Gábor; Balogh-Hergovich, E.; Giorgi, Michel; Simaan, A. Jalila; Párkányí, L.; Pap, J.; Kaizer, J.; Speier, G.

In: Inorganic Chemistry Communications, Vol. 14, No. 1, 01.2011, p. 205-209.

Research output: Contribution to journalArticle

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AU - Giorgi, Michel

AU - Simaan, A. Jalila

AU - Párkányí, L.

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