Az atípusos antipszichotikumok hatékonysága és a dopamin D3-receptor polimorfizmusának kapcsolata schizophreniában.

Translated title of the contribution: Correlation between the effectiveness of atypical antipsychotics and dopamine D3 receptor polymorphism in schizophrenia

Research output: Contribution to journalArticle

Abstract

OBJECT: Numerous relevant variants of dopamine receptors have been identified in schizophrenia. The Ser9Gly gene polymorphism of dopamine D3 receptor is known as a susceptibility factor for the disease. In addition, it has a role in the modification of therapeutic effect of antipsychotics. In this naturalistic study the authors investigated the relationship between this polymorphism and the therapeutic response to atypical antipsychotics. METHOD: 75 patients with schizophrenia according to DSM-IV and 45 healthy controls were recruited. The patients were divided to responder and nonresponder subgroups, cut-off: > 20 point improvement in Global Assessment of Functioning. By polymerase chain reaction the genotype of dopamine D3 receptor of every participant was determined. RESULTS: The Ser9Ser genotype of dopamine D3 receptor was more frequent in the nonresponder subgroup (64%, p = 0.0018). The Ser9 allele was overrepresented among nonresponder patients (82%, p = 0.0172). CONCLUSION: Based on our results, the worse therapeutic response to atypical antipsychotics is associated with Ser9 variant of dopamine D3 receptor.

Translated title of the contributionCorrelation between the effectiveness of atypical antipsychotics and dopamine D3 receptor polymorphism in schizophrenia
Original languageHungarian
Pages (from-to)377-381
Number of pages5
JournalIdeggyógyászati szemle
Volume55
Issue number11-12
Publication statusPublished - Nov 20 2002

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Correlation between the effectiveness of atypical antipsychotics and dopamine D3 receptor polymorphism in schizophrenia'. Together they form a unique fingerprint.

  • Cite this