Correlation between the alterations in the mRNA expressions of the α1-adrenoceptor and estrogen receptor subtypes in the pregnant human uterus and cervix

Eszter Ducza, Zsolt Kormányos, Béla Endre Resch, George Falkay

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Our present aim was to determine the association between the mRNA expressions of the estrogen and adrenoceptor subtypes in the pregnant human uterus and cervix. The presence of the mRNA expressions of all the α1-adrenoceptor and estrogen receptor subtypes in the uterus and cervix was proved by means of a reverse transcription polymerase chain reaction method, with a predominance of the mRNAs of the α1B- adrenoceptor and estrogen α receptors, respectively. The change in the mRNA expression of the estrogen receptor α correlated strongly with the change in mRNA level of the α1B-adrenoceptors. We presume that the expression of the α1B-adrenoceptors at 33-34 weeks in the pregnant human uterus is regulated by estrogen through the estrogen receptor α subtypes.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalEuropean Journal of Pharmacology
Volume528
Issue number1-3
DOIs
Publication statusPublished - Dec 28 2005

Keywords

  • Estrogen receptor subtypes
  • Pregnant human uterus
  • α-adrenoceptor subtypes

ASJC Scopus subject areas

  • Pharmacology

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