Correlation between structure and gas chromatographic behaviour of nitrogen-containing heterocyclic compounds. II. Alkyl substitution of quinazolone derivatives

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Abstract

Mono- and dialkyl-substituted quinazolones were synthesized by literature or its modifications. Six homologous series were prepared, varying in the substituent introduced and its position. The retention indices of the compounds were determined on OV-1 and OV-25 stationary phases. The influence of the number of carbon atoms in the homologues alkyl chain on the I and ΔI values could be characterized well. The behaviour of the alkylquinazolones and the ring-closed tricyclic with the same number of carbon atoms could also be characterized numerically. A dominant effect was exerted by the substituent in the neighbouring position to the alkyl chain.

Original languageEnglish
Pages (from-to)371-376
Number of pages6
JournalJournal of Chromatography A
Volume537
Issue numberC
DOIs
Publication statusPublished - 1991

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Heterocyclic Compounds
Substitution reactions
Nitrogen
Carbon
Gases
Derivatives
Atoms

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

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title = "Correlation between structure and gas chromatographic behaviour of nitrogen-containing heterocyclic compounds. II. Alkyl substitution of quinazolone derivatives",
abstract = "Mono- and dialkyl-substituted quinazolones were synthesized by literature or its modifications. Six homologous series were prepared, varying in the substituent introduced and its position. The retention indices of the compounds were determined on OV-1 and OV-25 stationary phases. The influence of the number of carbon atoms in the homologues alkyl chain on the I and ΔI values could be characterized well. The behaviour of the alkylquinazolones and the ring-closed tricyclic with the same number of carbon atoms could also be characterized numerically. A dominant effect was exerted by the substituent in the neighbouring position to the alkyl chain.",
author = "O. Papp and G. Sz{\'a}sz and L. Őrfi and I. Hermecz",
year = "1991",
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T1 - Correlation between structure and gas chromatographic behaviour of nitrogen-containing heterocyclic compounds. II. Alkyl substitution of quinazolone derivatives

AU - Papp, O.

AU - Szász, G.

AU - Őrfi, L.

AU - Hermecz, I.

PY - 1991

Y1 - 1991

N2 - Mono- and dialkyl-substituted quinazolones were synthesized by literature or its modifications. Six homologous series were prepared, varying in the substituent introduced and its position. The retention indices of the compounds were determined on OV-1 and OV-25 stationary phases. The influence of the number of carbon atoms in the homologues alkyl chain on the I and ΔI values could be characterized well. The behaviour of the alkylquinazolones and the ring-closed tricyclic with the same number of carbon atoms could also be characterized numerically. A dominant effect was exerted by the substituent in the neighbouring position to the alkyl chain.

AB - Mono- and dialkyl-substituted quinazolones were synthesized by literature or its modifications. Six homologous series were prepared, varying in the substituent introduced and its position. The retention indices of the compounds were determined on OV-1 and OV-25 stationary phases. The influence of the number of carbon atoms in the homologues alkyl chain on the I and ΔI values could be characterized well. The behaviour of the alkylquinazolones and the ring-closed tricyclic with the same number of carbon atoms could also be characterized numerically. A dominant effect was exerted by the substituent in the neighbouring position to the alkyl chain.

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U2 - 10.1016/S0021-9673(01)88910-X

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EP - 376

JO - Journal of Chromatography

JF - Journal of Chromatography

SN - 0021-9673

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