Correlation between structure and gas chromatographic behaviour of nitrogen-containing heterocyclic compounds. I. Methyl substitution of pyridopyrimidine derivatives

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Abstract

The methyl isomers of 4-oxopyridopyrimidine and tetrahydro-4-oxopyridopyrimidine and their 2,3-polymethylene derivatives were investigated. The compounds were characterized by their gas chromatographic retention indices measured on apolar and medium-polarity stationary phases. On the basis of the retention index increments, numerical values are given to characterize the shielding effects exerted on the polar centres of the molecule by methyl groups substituted at different positions. The steric and electronic effects are also characterized by retention index values.

Original languageEnglish
Pages (from-to)365-370
Number of pages6
JournalJournal of Chromatography A
Volume537
Issue numberC
DOIs
Publication statusPublished - 1991

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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