Correlation between structure and gas chromatographic behavior of nitrogen-containing heterocyclic compounds. III. Variation of ring size

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4 Citations (Scopus)

Abstract

Ring homologues of the desoxyvasicinone type, which exert an antiasthmatic effect, were investigated. The retention indices and the solvent-solute interactions (expressed by the dI and ΔI values) revealed that an increase in ring size led to a decrease in the polar character in the investigated heterocyclic rings, but not in the homocyclics. The dIMe values of methyl groups introduced at the same position in the ring homologues demonstrated that an increase in the number of ring atoms ensures conformational freedom in ring A that can be expressed by numerical data. The structural and conformational differences influencing the retention data were confirmed by NMR investigations.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalJournal of Chromatography A
Volume537
Issue numberC
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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