A p-53 expresszió és a klinikai rezisztencia összefüggésének vizsgálata hererákokban.

Translated title of the contribution: Correlation between p-53 expression and clinical resistance in testicular cancer

E. Hanna, I. Bodrogi, E. Institoris, M. Bak

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

One of the most common cellular gene which negatively regulates the cell cycle, thus functioning as tumour suppressor gene, is the p-53 gene. The presence of this mutated gene has been correlated with, the aggressiveness of several malignant neoplasmas. Expression of the p-53 gene product protein was screened in 55 untreated human germ cell testicular tumours, furthermore a relationship between p-53 expression and clinical resistance was investigated. Using monoclonal antibody and immunoenzyme staining elevated p-53 level could be demonstrated in nuclei of embryonal carcinoma (84%) and seminoma components (56%). Most of the choriocarcinoma cases showed positive staining. Teratomas expressed this antigen negatively or scarcely. In seminomas the highest level of p-53 was stated in stage I. In contrast the opposite tendency could be demonstrated in embryonal carcinomas where p-53 was ++ positive in stage III. Between the high level of p-53 and clinical resistance a converse correlation could be stated because the resistant tumours expressed no or low, the sensitive tumours high level of p-53 protein (P 0.01). These results suggest that elevated p-53 expression could be a prognostic marker of sensitivity in testis cancer.

Original languageHungarian
Pages (from-to)59-64
Number of pages6
JournalOrvosi hetilap
Volume137
Issue number2
Publication statusPublished - Jan 14 1996

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ASJC Scopus subject areas

  • Medicine(all)

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