Correlation between noradrenaline content of the brain and the number of granular vesicles in rat hypothalamus during nialamid administration

A. K. Pfeifer, D. Szabó, M. Palkovits, I. Ökrös

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The fine structure of ventromedial hypothalamic nucleus was studied in the rat with the electron microscope under circumstances of elevated brain monoamine level following treatment with a monoamine oxidase inhibitor Nialamid. The number of granular vesicles (size in diameter 450-1100 Å) in synaptic terminals increased after Nialamid treatment significantly, while their size did not change; the number of agranular vesicles remained unchanged. The time courses of the increase of granular vesicles and elevation of brain noradrenaline content were approximately parallel. It is inferred that the granular vesicles of size 450 to 1100 Å may possibly be the storage sites of noradrenaline.

Original languageEnglish
Pages (from-to)79-86
Number of pages8
JournalExperimental brain research
Volume5
Issue number2
DOIs
Publication statusPublished - Mar 1 1968

Keywords

  • Granular vesicles
  • Nialamid
  • Noradrenaline
  • Rat
  • Synapse
  • Ventromedial hypothalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Correlation between noradrenaline content of the brain and the number of granular vesicles in rat hypothalamus during nialamid administration'. Together they form a unique fingerprint.

  • Cite this