Correlation between flow-mediated dilation and erectile dysfunction

Imre Kovács, Albert Császár, Janos Toth, György Siller, Attila Farkas, Jeno Tarján, Judit Horváth, Akos Koller

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16 Citations (Scopus)

Abstract

We hypothesized that there is a correlation between the magnitude of endothelial-mediated dilation of brachial artery and erectile function in patients. Thus, flow-mediated dilation of the brachial artery (FMD)-used to assess the function of endothelium-was measured in 56 patients (aged ∼35 years) having erectile dysfunction for 6-12 months. The patients were grouped based on International Index of Erectile Dysfunction: severe (5-10), moderate (11-16), mild to moderate (17-21), and mild (22-25). As compared to the mild group (8.8 ± 1.7%), FMD was significantly reduced in the mild-to-moderate group (5.7 ± 1.1%), moderate group (5.3 ± 0.8%), and severe group (4.4 ± 0.6%). Also, there was a positive correlation between the magnitude of endothelial and erectile dysfunction. Patients were treated with the 5-phosphodiesterase inhibitor sildenafil, known to elevate vascular cGMP level and thus the vascular efficacy of internal nitric oxide, for 3 to 6 months prior to the study. The mean doses of sildenafil used were as follows: severe group, 100 mg/event; moderate group, 86.1 ± 21.4 mg/event; mild-to-moderate group, 71.8 ± 23.2 mg/event; mild group, 25 mg/event. We found a positive correlation between the sildenafil dose requirement and the severity of erectile dysfunction. On the bases on these findings, together with the known mechanism of action of sildenafil, we propose that vascular endothelial dysfunction could contribute to erectile dysfunction and that erectile dysfunction may be an early marker of peripheral vascular disease.

Original languageEnglish
Pages (from-to)148-153
Number of pages6
JournalJournal of cardiovascular pharmacology
Volume51
Issue number2
DOIs
Publication statusPublished - Feb 1 2008

Keywords

  • Brachial artery
  • Endothelium
  • Nitric oxide
  • Sildenafil
  • cGMP

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Kovács, I., Császár, A., Toth, J., Siller, G., Farkas, A., Tarján, J., Horváth, J., & Koller, A. (2008). Correlation between flow-mediated dilation and erectile dysfunction. Journal of cardiovascular pharmacology, 51(2), 148-153. https://doi.org/10.1097/FJC.0b013e31815e8514