Correlation between flow-mediated dilation and erectile dysfunction

Imre Kovács, A. Császár, Janos Toth, György Siller, Attila Farkas, Jeno Tarján, Judit Horváth, Akos Koller

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We hypothesized that there is a correlation between the magnitude of endothelial-mediated dilation of brachial artery and erectile function in patients. Thus, flow-mediated dilation of the brachial artery (FMD)-used to assess the function of endothelium-was measured in 56 patients (aged ∼35 years) having erectile dysfunction for 6-12 months. The patients were grouped based on International Index of Erectile Dysfunction: severe (5-10), moderate (11-16), mild to moderate (17-21), and mild (22-25). As compared to the mild group (8.8 ± 1.7%), FMD was significantly reduced in the mild-to-moderate group (5.7 ± 1.1%), moderate group (5.3 ± 0.8%), and severe group (4.4 ± 0.6%). Also, there was a positive correlation between the magnitude of endothelial and erectile dysfunction. Patients were treated with the 5-phosphodiesterase inhibitor sildenafil, known to elevate vascular cGMP level and thus the vascular efficacy of internal nitric oxide, for 3 to 6 months prior to the study. The mean doses of sildenafil used were as follows: severe group, 100 mg/event; moderate group, 86.1 ± 21.4 mg/event; mild-to-moderate group, 71.8 ± 23.2 mg/event; mild group, 25 mg/event. We found a positive correlation between the sildenafil dose requirement and the severity of erectile dysfunction. On the bases on these findings, together with the known mechanism of action of sildenafil, we propose that vascular endothelial dysfunction could contribute to erectile dysfunction and that erectile dysfunction may be an early marker of peripheral vascular disease.

Original languageEnglish
Pages (from-to)148-153
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume51
Issue number2
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Erectile Dysfunction
Dilatation
Blood Vessels
Brachial Artery
Phosphodiesterase 5 Inhibitors
Peripheral Vascular Diseases
Endothelium
Nitric Oxide
Sildenafil Citrate

Keywords

  • Brachial artery
  • cGMP
  • Endothelium
  • Nitric oxide
  • Sildenafil

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Correlation between flow-mediated dilation and erectile dysfunction. / Kovács, Imre; Császár, A.; Toth, Janos; Siller, György; Farkas, Attila; Tarján, Jeno; Horváth, Judit; Koller, Akos.

In: Journal of Cardiovascular Pharmacology, Vol. 51, No. 2, 02.2008, p. 148-153.

Research output: Contribution to journalArticle

Kovács, I, Császár, A, Toth, J, Siller, G, Farkas, A, Tarján, J, Horváth, J & Koller, A 2008, 'Correlation between flow-mediated dilation and erectile dysfunction', Journal of Cardiovascular Pharmacology, vol. 51, no. 2, pp. 148-153. https://doi.org/10.1097/FJC.0b013e31815e8514
Kovács, Imre ; Császár, A. ; Toth, Janos ; Siller, György ; Farkas, Attila ; Tarján, Jeno ; Horváth, Judit ; Koller, Akos. / Correlation between flow-mediated dilation and erectile dysfunction. In: Journal of Cardiovascular Pharmacology. 2008 ; Vol. 51, No. 2. pp. 148-153.
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