Correlation between circular dichroism data and biological activities of 2, 5 substituted enkephalin analogues

J. Soós, I. Berzétei, S. Bajusz, A. Z. Rónai

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The relative structural rigidity of enkephalin analogues characterized by the molar ellipticity data obtained from the circular dichroism spectra of peptides was correlated with the opioid agonist activities of compounds displayed in isolated, electrically stimulated longitudinal muscle strip of guinea-pig ileum and mouse vas deferens preparations. It was found that the so called μ receptors modelled by guinea-pig ileum preferred the analogues with high capacity to exist in folded form, whilst the so called δ receptors (mouse vas deferens) accepted flexible ligands as readily as rigid ones.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalLife Sciences
Volume27
Issue number2
DOIs
Publication statusPublished - Jan 1 1980

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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