Correlation between beta- and alpha-adrenergic receptor concentrations in human placenta

G. Falkay, K. Melis, L. Kovács

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

α2- and βadrenergic receptors in human placental membranes have been investigated using the radioligands [3H]-RX 821002 and [3H]-dihydroalprenolol, respectively. The specific binding of the α2-adrenoceptor antagonist RX 821002 confirms the presence of an α2-adrenoceptor in the human placenta, which has been characterized previously with [3H]-rauwolscine. The major finding presented here is a correlation between the α2- and βadrenergic receptor concentrations (r=0.765) in the human placenta at term. It is suggested that the α2/β adrenoceptor balance may play an important role in regulation of the vascular bed of the placenta. Determination of the α2/β ratio may help towards an understanding of the contractility of the placental vascular muscles.

Original languageEnglish
Pages (from-to)187-195
Number of pages9
JournalJournal of Receptors and Signal Transduction
Volume14
Issue number3-4
DOIs
Publication statusPublished - Jan 1 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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