Correlation between BCR-ABL Expression and Tumor Burden is Restricted to the Transition from Minor to Major Cytogenetic Response in Interferon Treated CML Patients: "A pre-Gleevec study"

László Kereskai, János A. Vass, Mária Kneif, László Pajor

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The interferon treatment of chronic myeloid leukaemia has been monitored by investigating the tumour burden as revealed by fluorescence in situ hybridization and the expression of BCR-ABL chimera determined by quantitative reverse transcription polymerase chain reaction. These parameters were obtained from the peripheral blood of 51 untreated and 104 follow-up patient samples. Poor corrrelation (r = .31) was found between BCR-ABL expression and tumor load in all samples as well as in untreated patients, and this correlation was even less in all follow-up cases (r = .28). Regarding chimera expression five order of magnitude difference existed in the untreated patients and this value dropped to two in those with complete cytogenetic response. Only the major and the complete cytogenetic response groups differed significantly (p .001) in the BCR-ABL expression from that of patients at diagnosis. Among the different cytogenetic response groups the only significant difference (p<.01) in the BCR-ABL expression was obtained between the major and the minor responders. In the individual patients not only correlated changes of residual tumour mass and chimera expression, but mainly independent changes of these two parameters were observed. This indicates that the BCR-ABL expression and the tumor burden are largely independent variables.

Original languageEnglish
Pages (from-to)174-179
Number of pages6
JournalPathology and Oncology Research
Volume9
Issue number3
DOIs
Publication statusPublished - Jan 1 2003

Keywords

  • Chronic myeloid leukaemia
  • Fluorescence in situ hybridisation
  • Molecular monitoring
  • Quantitative polymerase chain reaction

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Correlation between BCR-ABL Expression and Tumor Burden is Restricted to the Transition from Minor to Major Cytogenetic Response in Interferon Treated CML Patients: "A pre-Gleevec study"'. Together they form a unique fingerprint.

  • Cite this