Correlation between analgesia and the decrease of acetylcholine turnover rate in cortex and hippocampus elicited by morphine, meperidine, viminol R2 and azidomorphine

G. Zsilla, D. L. Cheney, G. Racagni, E. Costa

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Abstract

In rats, an ED50 for analgesia of morphine, meperidine, viminol R2 or azidomorphine decreases the turnover rate of acetylcholine (TR(ACh)) in cortex and hippocampus. These four analgetics fail to change the TR (ACh) in striatum when given in a dose range from ED30 for analgesia up to a cataleptic dose. Viminol S2, a nonanalgesic stereoisomer of viminol R2, fails to decrease the TR(ACh) in cortex and hippocampus. Naltrexone, an opiate antagonist, also fails to change the cortical and hippocampal TR (ACh) but it antagonizes the decrease in cortical and hippocampal TR(ACh) elicited by the four analgetics. Since the ED50 of these four analgetics fails to change the TR(ACh) in striatum which contains a high density of opiate receptors and intrinsic cholinergic neurons, but decreases the TR(ACh) in hippocampus and cortex which contain a low density of opiate receptors, it can be inferred that opiate receptors are not exclusively involved in the regulation of TR(ACh). However, the results suggest that certain cholinergic pathways participate in the mediation of analgesia.

Original languageEnglish
Pages (from-to)662-668
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Volume199
Issue number3
Publication statusPublished - 1976

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Meperidine
Analgesia
Morphine
Acetylcholine
Hippocampus
Opioid Receptors
Opiate Alkaloids
Naltrexone
Stereoisomerism
Cholinergic Neurons
viminol
azidomorphine
Cholinergic Agents

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "Correlation between analgesia and the decrease of acetylcholine turnover rate in cortex and hippocampus elicited by morphine, meperidine, viminol R2 and azidomorphine",
abstract = "In rats, an ED50 for analgesia of morphine, meperidine, viminol R2 or azidomorphine decreases the turnover rate of acetylcholine (TR(ACh)) in cortex and hippocampus. These four analgetics fail to change the TR (ACh) in striatum when given in a dose range from ED30 for analgesia up to a cataleptic dose. Viminol S2, a nonanalgesic stereoisomer of viminol R2, fails to decrease the TR(ACh) in cortex and hippocampus. Naltrexone, an opiate antagonist, also fails to change the cortical and hippocampal TR (ACh) but it antagonizes the decrease in cortical and hippocampal TR(ACh) elicited by the four analgetics. Since the ED50 of these four analgetics fails to change the TR(ACh) in striatum which contains a high density of opiate receptors and intrinsic cholinergic neurons, but decreases the TR(ACh) in hippocampus and cortex which contain a low density of opiate receptors, it can be inferred that opiate receptors are not exclusively involved in the regulation of TR(ACh). However, the results suggest that certain cholinergic pathways participate in the mediation of analgesia.",
author = "G. Zsilla and Cheney, {D. L.} and G. Racagni and E. Costa",
year = "1976",
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volume = "199",
pages = "662--668",
journal = "Journal of Pharmacology and Experimental Therapeutics",
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T1 - Correlation between analgesia and the decrease of acetylcholine turnover rate in cortex and hippocampus elicited by morphine, meperidine, viminol R2 and azidomorphine

AU - Zsilla, G.

AU - Cheney, D. L.

AU - Racagni, G.

AU - Costa, E.

PY - 1976

Y1 - 1976

N2 - In rats, an ED50 for analgesia of morphine, meperidine, viminol R2 or azidomorphine decreases the turnover rate of acetylcholine (TR(ACh)) in cortex and hippocampus. These four analgetics fail to change the TR (ACh) in striatum when given in a dose range from ED30 for analgesia up to a cataleptic dose. Viminol S2, a nonanalgesic stereoisomer of viminol R2, fails to decrease the TR(ACh) in cortex and hippocampus. Naltrexone, an opiate antagonist, also fails to change the cortical and hippocampal TR (ACh) but it antagonizes the decrease in cortical and hippocampal TR(ACh) elicited by the four analgetics. Since the ED50 of these four analgetics fails to change the TR(ACh) in striatum which contains a high density of opiate receptors and intrinsic cholinergic neurons, but decreases the TR(ACh) in hippocampus and cortex which contain a low density of opiate receptors, it can be inferred that opiate receptors are not exclusively involved in the regulation of TR(ACh). However, the results suggest that certain cholinergic pathways participate in the mediation of analgesia.

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