Correlation between α1/β-adrenoceptor ratio and spontaneous uterine motor activity in the post-partum rat

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Abstract

The spontaneous uterine motor activity of the post-partum rat was investigated in parallel with the in-vitro determination of the density of the α1 and β adrenergic receptors of the myometrium. The in-vivo experiments were performed by an improved method, using a Millar catheter fitted with a latex microballoon. The spontaneous contractility of the post- partum rat uterus was found to be highest 24 h after delivery, indicating that this time is the most suitable for pharmacological examinations of tocolytic agents. A very close correlation was found between the results of the in-vivo experiments and the α1/β-adrenergic receptor ratio assessed by an in-vitro receptor assay, thus indicating that the state of the adrenergic receptor system fundamentally determines the contractility of the uterus. This conclusion is supposed by the fact that the pharmacological sensibly of the rat uterus to prazosin and fenoterol changed as a function of the post- partum time in accordance with the α1/β-adrenoceptor ratio. These results and the relevant data available reveal a crucially important role of an α1- adrenoceptor-mediated process, implicating α1-blockers as theoretically potent agents for inhibition of premature uterine contractions.

Original languageEnglish
Pages (from-to)921-924
Number of pages4
JournalMolecular Human Reproduction
Volume4
Issue number9
DOIs
Publication statusPublished - Sep 1998

Fingerprint

Adrenergic Receptors
Motor Activity
Uterus
Pharmacology
Tocolytic Agents
Fenoterol
Uterine Contraction
Myometrium
Prazosin
Latex
Catheters
In Vitro Techniques

Keywords

  • Adrenergic receptors
  • Post-partum rat
  • Tocolysis
  • Uterine contractility

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Genetics
  • Developmental Biology
  • Embryology
  • Cell Biology

Cite this

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abstract = "The spontaneous uterine motor activity of the post-partum rat was investigated in parallel with the in-vitro determination of the density of the α1 and β adrenergic receptors of the myometrium. The in-vivo experiments were performed by an improved method, using a Millar catheter fitted with a latex microballoon. The spontaneous contractility of the post- partum rat uterus was found to be highest 24 h after delivery, indicating that this time is the most suitable for pharmacological examinations of tocolytic agents. A very close correlation was found between the results of the in-vivo experiments and the α1/β-adrenergic receptor ratio assessed by an in-vitro receptor assay, thus indicating that the state of the adrenergic receptor system fundamentally determines the contractility of the uterus. This conclusion is supposed by the fact that the pharmacological sensibly of the rat uterus to prazosin and fenoterol changed as a function of the post- partum time in accordance with the α1/β-adrenoceptor ratio. These results and the relevant data available reveal a crucially important role of an α1- adrenoceptor-mediated process, implicating α1-blockers as theoretically potent agents for inhibition of premature uterine contractions.",
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AU - Márki, A.

AU - Gáspár, R.

AU - Falkay, G.

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