Correlates of parathyroid hormone concentration in hemodialysis patients

Jinnan Li, M. Molnár, Joshua J. Zaritsky, John J. Sim, Elani Streja, Csaba P. Kovesdy, Isidro Salusky, Kamyar Kalantar-Zadeh

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

BackgroundThe implications of chemical hyperparathyroidism on bone and mineral metabolism measures in maintenance hemodialysis (MHD) are not well known. We hypothesized that a higher serum intact parathyroid hormone (iPTH) level is associated with the higher likelihood of hyperphosphatemia, hyperphosphatasemia [high serum alkaline phosphatase (ALP) levels] and hypercalcemia.MethodsOver an 8-year period (July 2001-June 2009), we identified 106 760 MHD patients with iPTH and calcium (Ca), phosphorous (P) and ALP data from a large dialysis clinic. Logistic regression models were examined to assess the association between serum iPTH increments and the likelihood of hyperphosphatemia (P ≥5.5 mg/dL), hypercalcemia (Ca ≥10.2 mg/dL) and hyperphosphatasemia (ALP ≥120 U/L).ResultsPatients were 61 ± 16 years old and included 45% women, 59% diabetics and 33% Blacks. Compared with an iPTH level of 100 to

Original languageEnglish
Pages (from-to)1516-1525
Number of pages10
JournalNephrology Dialysis Transplantation
Volume28
Issue number6
DOIs
Publication statusPublished - Jun 2013

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Parathyroid Hormone
Renal Dialysis
Hyperphosphatemia
Alkaline Phosphatase
Hypercalcemia
Logistic Models
Serum
Calcium
Hyperparathyroidism
Minerals
Dialysis
Maintenance
Bone and Bones

Keywords

  • Hemodialysis
  • Serum alkaline phosphatase
  • Serum calcium
  • Serum intact parathyroid hormone
  • Serum phosphorous

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Li, J., Molnár, M., Zaritsky, J. J., Sim, J. J., Streja, E., Kovesdy, C. P., ... Kalantar-Zadeh, K. (2013). Correlates of parathyroid hormone concentration in hemodialysis patients. Nephrology Dialysis Transplantation, 28(6), 1516-1525. https://doi.org/10.1093/ndt/gfs598

Correlates of parathyroid hormone concentration in hemodialysis patients. / Li, Jinnan; Molnár, M.; Zaritsky, Joshua J.; Sim, John J.; Streja, Elani; Kovesdy, Csaba P.; Salusky, Isidro; Kalantar-Zadeh, Kamyar.

In: Nephrology Dialysis Transplantation, Vol. 28, No. 6, 06.2013, p. 1516-1525.

Research output: Contribution to journalArticle

Li, J, Molnár, M, Zaritsky, JJ, Sim, JJ, Streja, E, Kovesdy, CP, Salusky, I & Kalantar-Zadeh, K 2013, 'Correlates of parathyroid hormone concentration in hemodialysis patients', Nephrology Dialysis Transplantation, vol. 28, no. 6, pp. 1516-1525. https://doi.org/10.1093/ndt/gfs598
Li, Jinnan ; Molnár, M. ; Zaritsky, Joshua J. ; Sim, John J. ; Streja, Elani ; Kovesdy, Csaba P. ; Salusky, Isidro ; Kalantar-Zadeh, Kamyar. / Correlates of parathyroid hormone concentration in hemodialysis patients. In: Nephrology Dialysis Transplantation. 2013 ; Vol. 28, No. 6. pp. 1516-1525.
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