Coronary vasospasm as a source of false positive results during dobutamine echocardiography.

A. Varga, L. Cortigiani, P. C. Rossi, E. Cseh, M. De Nes, M. G. Trivieri, M. Csanády, E. Picano

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

BACKGROUND: Several studies have demonstrated a consistently high sensitivity of dobutamine echocardiography whereas test specificity in these series has been variable. The aim of this study was to evaluate whether coronary vasospasm--elicited by alpha1 adrenoreceptor stimulation--may be a significant source of false positive responses during dobutamine stress. METHODS: From the data bank of four institutions we selected 113 patients (75 males, 38 females, mean age 55 +/- 12 years) with dobutamine echocardiography performed (up to 40 micrograms/kg/min and atropine 1 mg if needed) before a coronary angiography showing normal or near normal (visually assessed stenosis severity <50%) coronary arteries. The following variables--which were previously reported influencing dobutamine echo specificity--entered the multivariate statistical analysis: age, sex, heart rate at baseline and at peak stress, baseline echo, hypertension, site of asynergy, and spasm at coronary angiography. RESULTS: Twenty-five patients had a positive dobutamine test. The positivity occurred in the left coronary territory in 15 and in the right coronary territory in 10 cases. All the 6 patients with spontaneous spasm during angiography had a false positive stress test result. By multivariate analysis only coronary artery spasm during angiography (p = 0.0015) and history of hypertension (p = 0.0031) were significant predictors of false positive results of dobutamine stress echocardiography. CONCLUSIONS: Coronary artery spasm may be an important source of false positive results during dobutamine stress echocardiography.

Original languageEnglish
Pages (from-to)907-912
Number of pages6
JournalCardiologia
Volume44
Issue number10
Publication statusPublished - Oct 1999

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Coronary Vasospasm
Dobutamine
Echocardiography
Spasm
Stress Echocardiography
Coronary Vessels
Coronary Angiography
Angiography
Multivariate Analysis
Hypertension
Atropine
Exercise Test
Pathologic Constriction
Heart Rate
Databases

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Varga, A., Cortigiani, L., Rossi, P. C., Cseh, E., De Nes, M., Trivieri, M. G., ... Picano, E. (1999). Coronary vasospasm as a source of false positive results during dobutamine echocardiography. Cardiologia, 44(10), 907-912.

Coronary vasospasm as a source of false positive results during dobutamine echocardiography. / Varga, A.; Cortigiani, L.; Rossi, P. C.; Cseh, E.; De Nes, M.; Trivieri, M. G.; Csanády, M.; Picano, E.

In: Cardiologia, Vol. 44, No. 10, 10.1999, p. 907-912.

Research output: Contribution to journalArticle

Varga, A, Cortigiani, L, Rossi, PC, Cseh, E, De Nes, M, Trivieri, MG, Csanády, M & Picano, E 1999, 'Coronary vasospasm as a source of false positive results during dobutamine echocardiography.', Cardiologia, vol. 44, no. 10, pp. 907-912.
Varga A, Cortigiani L, Rossi PC, Cseh E, De Nes M, Trivieri MG et al. Coronary vasospasm as a source of false positive results during dobutamine echocardiography. Cardiologia. 1999 Oct;44(10):907-912.
Varga, A. ; Cortigiani, L. ; Rossi, P. C. ; Cseh, E. ; De Nes, M. ; Trivieri, M. G. ; Csanády, M. ; Picano, E. / Coronary vasospasm as a source of false positive results during dobutamine echocardiography. In: Cardiologia. 1999 ; Vol. 44, No. 10. pp. 907-912.
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