Coronary vascular endothelium-myocyte interactions in protection of the heart by ischaemic preconditioning

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Abstract

Because ischaemia preconditioning is a general phenomenon - it is present in almost all tissues and organs - we must look for a mechanism which involves cell types common to all organs. The hypothesis outlined below is that endothelial cells, in response to a brief ischaemic stimulus, release protective mediators which (in the heart) diffuse to cardiac myocytes to increase resistance to a subsequent ischaemic stress. These substances include nitric oxide, generated through initial bradykinin release, and prostacyclin. The evidence includes measurement of mediator release and the pharmacological attenuation of the antiarrythmic effects of preconditioning by blockade of bradykinin receptors and inhibition of nitric oxide production.

Original languageEnglish
Pages (from-to)509-524
Number of pages16
JournalJournal of Physiology and Pharmacology
Volume50
Issue number4
Publication statusPublished - Dec 1 1999

Keywords

  • Bradykinin
  • Endothelial-myocyte interactions
  • Myocardial protection
  • Nitric oxite
  • Preconditioning

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

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