Coronary artery bypass surgery provokes alzheimer's disease-like changes in the cerebrospinal fluid

András Palotás, Helton J. Reis, G. Bogáts, Barna Babik, Mihály Racsmány, Linda Engvau, Éva Kecskeméti, A. Juhász, Luciene B. Vieira, Antônio L. Teixeira, Marat A. Mukhamedyarov, Albert A. Rizvanov, Mehmet E. Yalvaç, Melissa M. Guimarêes, Cláudia N. Ferreira, Andrey L. Zefirov, Andrey P. Kiyasov, Lan Wang, Z. Janka, J. Kálmán

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Several biomarkers are used in confirming the diagnosis of cognitive disorders. This study evaluates whether the level of these markers after heart surgery correlates with the development of cognitive dysfunction, which is a frequent complication of cardiac interventions. Concentrations of amyloid-β peptide, tau, and S100β in the cerebro-spinal fluid were assessed, as well as cognitive functions were evaluated before and after coronary artery bypass grafting, utilizing immuno-assays and psychometric tests, respectively. A drastic rise in the level of S100β was observed one week after the surgery, a mark of a severe generalized cerebral injury. The level of amyloid-β peptide significantly decreased, whereas the concentration of tau markedly increased six months postoperatively. Gradual cognitive decline was also present. These findings clearly demonstrate post-surgical cognitive impairment associated with changes in biomarkers similar to that seen in Alzheimer's disease, suggesting a unifying pathognomic factor between the two disorders. A holistic approach to coronary heart disease and Alzheimer's-type dementia is proposed.

Original languageEnglish
Pages (from-to)1153-1164
Number of pages12
JournalJournal of Alzheimer's Disease
Volume21
Issue number4
DOIs
Publication statusPublished - 2010

Fingerprint

Coronary Artery Bypass
Cerebrospinal Fluid
Alzheimer Disease
Amyloid
Biomarkers
Peptides
Psychometrics
Cognition
Thoracic Surgery
Coronary Disease
Wounds and Injuries
Cognitive Dysfunction

Keywords

  • Alzheimer's disease
  • amyloid-β peptide
  • biomarker
  • cardiac surgery
  • cerebrospinal fluid
  • cognitive function
  • postoperative cognitive decline
  • S100β
  • tau

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Coronary artery bypass surgery provokes alzheimer's disease-like changes in the cerebrospinal fluid. / Palotás, András; Reis, Helton J.; Bogáts, G.; Babik, Barna; Racsmány, Mihály; Engvau, Linda; Kecskeméti, Éva; Juhász, A.; Vieira, Luciene B.; Teixeira, Antônio L.; Mukhamedyarov, Marat A.; Rizvanov, Albert A.; Yalvaç, Mehmet E.; Guimarêes, Melissa M.; Ferreira, Cláudia N.; Zefirov, Andrey L.; Kiyasov, Andrey P.; Wang, Lan; Janka, Z.; Kálmán, J.

In: Journal of Alzheimer's Disease, Vol. 21, No. 4, 2010, p. 1153-1164.

Research output: Contribution to journalArticle

Palotás, A, Reis, HJ, Bogáts, G, Babik, B, Racsmány, M, Engvau, L, Kecskeméti, É, Juhász, A, Vieira, LB, Teixeira, AL, Mukhamedyarov, MA, Rizvanov, AA, Yalvaç, ME, Guimarêes, MM, Ferreira, CN, Zefirov, AL, Kiyasov, AP, Wang, L, Janka, Z & Kálmán, J 2010, 'Coronary artery bypass surgery provokes alzheimer's disease-like changes in the cerebrospinal fluid', Journal of Alzheimer's Disease, vol. 21, no. 4, pp. 1153-1164. https://doi.org/10.3233/JAD-2010-100702
Palotás, András ; Reis, Helton J. ; Bogáts, G. ; Babik, Barna ; Racsmány, Mihály ; Engvau, Linda ; Kecskeméti, Éva ; Juhász, A. ; Vieira, Luciene B. ; Teixeira, Antônio L. ; Mukhamedyarov, Marat A. ; Rizvanov, Albert A. ; Yalvaç, Mehmet E. ; Guimarêes, Melissa M. ; Ferreira, Cláudia N. ; Zefirov, Andrey L. ; Kiyasov, Andrey P. ; Wang, Lan ; Janka, Z. ; Kálmán, J. / Coronary artery bypass surgery provokes alzheimer's disease-like changes in the cerebrospinal fluid. In: Journal of Alzheimer's Disease. 2010 ; Vol. 21, No. 4. pp. 1153-1164.
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