Corneal ulcer due to Neocosmospora vasinfecta in an immunocompetent patient

Palanisamy Manikandan, H. F. Vismer, L. Kredics, I. Dóczi, W. F O Marasas, M. Bhaskar, R. Anita, R. Revathi, V. Narendran

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We report a case of Neocosmospora vasinfecta keratitis in a 55-year-old man. While the patient did not recall any specific trauma or eye injury, he might have sustained a trivial wound during the course of his duties as a farmer. Direct examination of corneal scrapings revealed fungal filaments. As topical treatment with natamycin and econazole and subsequent systemic ketoconazole therapy failed, a full thickness therapeutic keratoplasty was performed. Post-operative treatment with amphotericin B and clotrimazole combined with cyclosporine resulted in a complete cure. The residual corneal infiltration in the recipient cornea became clear in a week. The fungal isolate was initially identified as a Fusarium species, but later reidentified through the use of morphological characteristics and sequence analysis of the internal transcribed spacer region as N. vasinfecta. The latters is a Hypocrealean fungus not hitherto reported as a causative agent of keratomycosis.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalMedical Mycology
Volume46
Issue number3
DOIs
Publication statusPublished - 2008

Fingerprint

Neocosmospora vasinfecta
Corneal Ulcer
natamycin
clotrimazole
keratitis
ketoconazole
therapeutics
cyclosporine
amphotericin B
cornea
Fusarium
internal transcribed spacers
sequence analysis
eyes
Natamycin
Econazole
farmers
case studies
Clotrimazole
Eye Injuries

Keywords

  • Corneal ulcer
  • India
  • Keratomycosis
  • Neocosmospora vasinfecta

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • veterinary(all)
  • Microbiology

Cite this

Manikandan, P., Vismer, H. F., Kredics, L., Dóczi, I., Marasas, W. F. O., Bhaskar, M., ... Narendran, V. (2008). Corneal ulcer due to Neocosmospora vasinfecta in an immunocompetent patient. Medical Mycology, 46(3), 279-284. https://doi.org/10.1080/13693780701625149

Corneal ulcer due to Neocosmospora vasinfecta in an immunocompetent patient. / Manikandan, Palanisamy; Vismer, H. F.; Kredics, L.; Dóczi, I.; Marasas, W. F O; Bhaskar, M.; Anita, R.; Revathi, R.; Narendran, V.

In: Medical Mycology, Vol. 46, No. 3, 2008, p. 279-284.

Research output: Contribution to journalArticle

Manikandan, P, Vismer, HF, Kredics, L, Dóczi, I, Marasas, WFO, Bhaskar, M, Anita, R, Revathi, R & Narendran, V 2008, 'Corneal ulcer due to Neocosmospora vasinfecta in an immunocompetent patient', Medical Mycology, vol. 46, no. 3, pp. 279-284. https://doi.org/10.1080/13693780701625149
Manikandan, Palanisamy ; Vismer, H. F. ; Kredics, L. ; Dóczi, I. ; Marasas, W. F O ; Bhaskar, M. ; Anita, R. ; Revathi, R. ; Narendran, V. / Corneal ulcer due to Neocosmospora vasinfecta in an immunocompetent patient. In: Medical Mycology. 2008 ; Vol. 46, No. 3. pp. 279-284.
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