Corneal ulcer due to Neocosmospora vasinfecta in an immunocompetent patient

Palanisamy Manikandan, H. F. Vismer, L. Kredics, I. Doczi, W. F.O. Marasas, M. Bhaskar, R. Anita, R. Revathi, V. Narendran

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We report a case of Neocosmospora vasinfecta keratitis in a 55-year-old man. While the patient did not recall any specific trauma or eye injury, he might have sustained a trivial wound during the course of his duties as a farmer. Direct examination of corneal scrapings revealed fungal filaments. As topical treatment with natamycin and econazole and subsequent systemic ketoconazole therapy failed, a full thickness therapeutic keratoplasty was performed. Post-operative treatment with amphotericin B and clotrimazole combined with cyclosporine resulted in a complete cure. The residual corneal infiltration in the recipient cornea became clear in a week. The fungal isolate was initially identified as a Fusarium species, but later reidentified through the use of morphological characteristics and sequence analysis of the internal transcribed spacer region as N. vasinfecta. The latters is a Hypocrealean fungus not hitherto reported as a causative agent of keratomycosis.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalMedical mycology
Issue number3
Publication statusPublished - Sep 4 2008


  • Corneal ulcer
  • India
  • Keratomycosis
  • Neocosmospora vasinfecta

ASJC Scopus subject areas

  • Infectious Diseases

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    Manikandan, P., Vismer, H. F., Kredics, L., Doczi, I., Marasas, W. F. O., Bhaskar, M., Anita, R., Revathi, R., & Narendran, V. (2008). Corneal ulcer due to Neocosmospora vasinfecta in an immunocompetent patient. Medical mycology, 46(3), 279-284.