Copying and evolution of neuronal topology

Chrisantha Fernando, K. K. Karishma, Eörs Szathmáry

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

We propose a mechanism for copying of neuronal networks that is of considerable interest for neuroscience for it suggests a neuronal basis for causal inference, function copying, and natural selection within the human brain. To date, no model of neuronal topology copying exists. We present three increasingly sophisticated mechanisms to demonstrate how topographic map formation coupled with Spike-Time Dependent Plasticity (STDP) can copy neuronal topology motifs. Fidelity is improved by error correction and activity-reverberation limitation. The high-fidelity topology-copying operator is used to evolve neuronal topologies. Possible roles for neuronal natural selection are discussed.

Original languageEnglish
Article numbere3775
JournalPloS one
Volume3
Issue number11
DOIs
Publication statusPublished - Nov 20 2008

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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