Copper(II) fluoride a new efficient promoter of Chan-Lam-Evans coupling

Balázs Komjáti, Bianka Szokol, L. Poppe, József Nagy

Research output: Contribution to journalArticle

Abstract

The Chan-Lam-Evans coupling is the copper(II) acetate promoted reaction of phenols and boronic acids producing diaryl ethers. In this paper a modification of the original reaction is reported using copper(II) fluoride reagent which gives higher yields than copper(II) acetate. The most significant increase in yield was observed in formation of sterically hindered phenols. We hypothesize that fluoride ions help to cleave the boron-carbon bond. The novel method is suitable for selective, efficient and economical synthesis of diaryl ether compounds under mild conditions.

Original languageEnglish
Pages (from-to)243-245
Number of pages3
JournalPeriodica Polytechnica: Chemical Engineering
Volume59
Issue number4
DOIs
Publication statusPublished - 2015

Fingerprint

Phenols
Fluorides
Copper
Boronic Acids
Boron
Ethers
Ether
Carbon
Ions
Acids
cupric acetate

Keywords

  • Boronic acid
  • Copper(II) fluoride
  • Cross coupling
  • Diaryl ether

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Copper(II) fluoride a new efficient promoter of Chan-Lam-Evans coupling. / Komjáti, Balázs; Szokol, Bianka; Poppe, L.; Nagy, József.

In: Periodica Polytechnica: Chemical Engineering, Vol. 59, No. 4, 2015, p. 243-245.

Research output: Contribution to journalArticle

Komjáti, Balázs ; Szokol, Bianka ; Poppe, L. ; Nagy, József. / Copper(II) fluoride a new efficient promoter of Chan-Lam-Evans coupling. In: Periodica Polytechnica: Chemical Engineering. 2015 ; Vol. 59, No. 4. pp. 243-245.
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