Copper(II) complexes with reduced schiff base: Synthesis, spectroscopic, thermal, X-ray, and cytotoxic studies of novel copper(II) complexes with an arylpyrazole ligand

Vukadin M. Leovac, Petra Bombicz, Katalin Mészáros Szécsényi, Milan D. Joksović

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The synthesis of a novel arylpyrazole-derived ligand, 1,2-bis[(1,3- diphenylpyrazol-4-yl)methyl]diaminoethane (Ph4Pz2mde), and its complexes prepared with CuCl2 [Cu(Ph4Pz 2mde)Cl2(MeOH)] 1, CuBr2 [Cu(Ph 4Pz2mde)Br2(MeOH)] 2, from MeOH, and [Cu(Ph4Pz2mde)Cl2(DMF)] 3, from a mixture of MeOH and DMF, are described. The complexes are characterized by elemental and thermal analysis and FT-IR spectroscopy, while the 1H and 13C NMR assignments are given for the ligand. The crystal and molecular structure of [Cu(Ph4Pz2mde)Cl2(DMF)] was determined by single-crystal X-ray diffraction. In-vitro cytotoxicity of the Ph4Pz2mde ligand and two copper(ii) complexes was obtained using sulforhodamine B (SRB) treatment against three human tumour cell lines: HeLa (epitheloid carcinoma of cervix), MCF-7 (breast adenocarcinoma), and MRC-5 (lung fetal fibroblasts).

Original languageEnglish
Pages (from-to)615-620
Number of pages6
JournalAustralian Journal of Chemistry
Volume60
Issue number8
DOIs
Publication statusPublished - Aug 15 2007

ASJC Scopus subject areas

  • Chemistry(all)

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