Copper(II) complexes of amino acid derivatives of the bis(imidazol-2-yl) methyl residue

C. Kállay, Manuela Cattari, Daniele Sanna, K. Várnagy, H. Süli-Vargha, A. Csámpai, I. Sóvágó, Giovanni Micera

Research output: Contribution to journalArticle

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Abstract

Copper(II) complexes of amino acid derivatives of bis(imidazol-2-yl) methylamine (BIMA), α-Asp-BIMA, α-Glu-BIMA, γ-Glu-BIMA and β-Ala-BIMA, were studied by potentiometric, UV-VIS and EPR techniques. The bis(imidazol-2-yl)methyl residue is the main binding site in strong acidic medium in all cases. The formation of ligand-bridged dinuclear [Cu 2L2]2+ species was detected in an equimolar solution of α-Asp-BIMA and γ-Glu-BIMA with binding of the N-terminal amino and carboxylate groups. The deprotonation of amide nitrogen takes place above pH 6 for the ligands containing an amide group in a chelatable position with terminal amino group (α-Asp-BIMA, α-Glu-BIMA and β-Ala-BIMA), resulting in the formation of dinuclear [CU2H -2L2] species with imidazole bridging. For these 3 ligands, deprotonation of the pyrrole-type nitrogen was observed and the existence of a trinuclear species [Cu3H-4L2] was assumed in alkaline solution. This species contains negatively charged imidazolato bridges.

Original languageEnglish
Pages (from-to)727-734
Number of pages8
JournalNew Journal of Chemistry
Volume28
Issue number6
DOIs
Publication statusPublished - Jun 2004

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Amino acids
Copper
Deprotonation
Ligands
Derivatives
Amides
Amino Acids
Nitrogen
Pyrroles
Binding sites
Paramagnetic resonance
Binding Sites
imidazole
methylamine

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Copper(II) complexes of amino acid derivatives of the bis(imidazol-2-yl) methyl residue. / Kállay, C.; Cattari, Manuela; Sanna, Daniele; Várnagy, K.; Süli-Vargha, H.; Csámpai, A.; Sóvágó, I.; Micera, Giovanni.

In: New Journal of Chemistry, Vol. 28, No. 6, 06.2004, p. 727-734.

Research output: Contribution to journalArticle

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AU - Várnagy, K.

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AU - Csámpai, A.

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