Copper(II) and nickel(II) ternary complexes of l-dopa and related compounds

T. Kiss, A. Gergely

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The stability constants of the mixed ligand complexes of L-dopa, L-tyrosine, L-phenylalanine, and dopamine with copper(II) and nickel(II) ions and with 2,2'-bipyridyl and 1,10-phenanthroline were determined pH-metrically at 25°C and an ionic strength of 0.2 mol dm3 (KCl). Spectral studies were made to establish the binding mode of the ambidentate L-dopa in the ternary complexes. In contrast with the aromatic (N,N) donor atoms, the (0,0) binding mode of L-dopa is particularly favored in its ternary systems with copper(II) and nickel(II); thus, even at physiological pH there is a very considerable formation of (0,0)-bound mixed ligand complexes containing a free amino acid side-chain. Numerous binary transition metal-L-dopa complexes and the ternary complexes formed with various B ligands have been evaluated from a coordination chemistry aspect, with regard to the possibility of their therapeutic application in the treatment of Parkinson disease.

Original languageEnglish
Pages (from-to)247-259
Number of pages13
JournalJournal of Inorganic Biochemistry
Volume25
Issue number4
DOIs
Publication statusPublished - Dec 1985

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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