Copper on iron promoted one-pot synthesis of β-aminoenones and 3,5-disubstituted pyrazoles

Szabolcs Kovács, Zoltán Novák

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The reaction of hydroximoyl chlorides with acetylenes in the presence of a copper on iron bimetallic system leads to β-aminoenones via reductive ring opening of isoxazole intermediates. The valuable β-aminoenone building blocks can be isolated or transformed into pyrazoles with the addition of hydrazine in a straightforward one-pot procedure.

Original languageEnglish
Pages (from-to)8987-8993
Number of pages7
JournalTetrahedron
Volume69
Issue number43
DOIs
Publication statusPublished - Oct 28 2013

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Keywords

  • Copper
  • Enones
  • Heterocycles
  • Iron
  • Reduction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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