Copper-induced non-selective permeability changes in intracellularly perfused snail neurons

T. Kiss, J. Gyori, O. N. Osipenko, S. B. Maginyan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of extracellularly applied Cu2+ was studied on isolated intracellularly perfused Helix pomatia neurons. It was found that the Cu2+-activated current (I(Cu)) is biphasic and composed of overlapping outward and inward components. The outward component of I(Cu) is the result of a blockade by Cu2+ of the steady-state outward Cl- current. The inward component is assumed to flow through Ca2+-activated non-selective cationic channels. The washing-out procedure resulted in a large inward current (I(w)), which was composed of transient and steady-state components. It is most likely that the activation of metabolic pumps is responsible for the transient component and the steady-state component is the result of increased neuronal membrane permeability for Cl-. Moreover, both I(Cu) and I(w) were highly Ca2+- and temperature-dependent processes. It is concluded that Cu2+ application resulted in complex permeability changes in the Helix pomatia neurons.

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalJournal of Applied Toxicology
Volume11
Issue number5
Publication statusPublished - 1991

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Snails
Neurons
Copper
Permeability
Membrane Transport Proteins
Washing
Chemical activation
Membranes
Temperature

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Copper-induced non-selective permeability changes in intracellularly perfused snail neurons. / Kiss, T.; Gyori, J.; Osipenko, O. N.; Maginyan, S. B.

In: Journal of Applied Toxicology, Vol. 11, No. 5, 1991, p. 349-354.

Research output: Contribution to journalArticle

Kiss, T. ; Gyori, J. ; Osipenko, O. N. ; Maginyan, S. B. / Copper-induced non-selective permeability changes in intracellularly perfused snail neurons. In: Journal of Applied Toxicology. 1991 ; Vol. 11, No. 5. pp. 349-354.
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