Copper-free Sonogashira coupling in amine-water solvent mixtures

Anna Komáromi, Gergely László Tolnai, Z. Novák

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Extensive study of different amine-water solvent mixtures was carried out for copper free Sonogashira coupling of aryl iodides. The influence of the palladium sources, ligands, amine-water ratio and further additives was also evaluated. Application of sec-butylamine-water mixture proved to be an excellent medium for rapid and efficient coupling of aryl-iodides at ambient temperature in the presence of PdCl2(PPh3)2 as catalyst.

Original languageEnglish
Pages (from-to)7294-7298
Number of pages5
JournalTetrahedron Letters
Volume49
Issue number51
DOIs
Publication statusPublished - Dec 15 2008

Fingerprint

Amines
Copper
Iodides
Water
Butylamines
Palladium
Ligands
Catalysts
Temperature
palladium chloride

Keywords

  • Acetylenes
  • Cross-coupling
  • Palladium
  • Sonogashira reaction

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Copper-free Sonogashira coupling in amine-water solvent mixtures. / Komáromi, Anna; Tolnai, Gergely László; Novák, Z.

In: Tetrahedron Letters, Vol. 49, No. 51, 15.12.2008, p. 7294-7298.

Research output: Contribution to journalArticle

Komáromi, Anna ; Tolnai, Gergely László ; Novák, Z. / Copper-free Sonogashira coupling in amine-water solvent mixtures. In: Tetrahedron Letters. 2008 ; Vol. 49, No. 51. pp. 7294-7298.
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