Coordination of initiation of nuclear division and initiation of cell division in Schizosaccharomyces pombe: Genetic interactions of mutations

A. Grallert, B. Grallert, B. Ribar, M. Sipiczki

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

sep1+ encodes a Schizosaccharomyces pombe homolog of the HNF-3/forkhead family of the tissue-specific and developmental gene regulators identified in higher eukaryotes. Its mutant allele sep1-1 causes a defect in cytokinesis and confers a mycelial morphology. Here we report on genetic interactions of sep1-1 with the M-phase initiation mutations wee1-, cdc2-1w, and cdc25-22. The double mutants sep1-1 wee1- and sep1-1 cdc2-1w form dikaryon cells at high frequency, which is due to nuclear division in the absence of cell division. The dikaryosis is reversible and suppressible by cdc25-22. We propose that the genes wee1+, cdc2+, cdc25+, and sep1+ form a regulatory link between the initiation of mitosis and the initiation of cell division.

Original languageEnglish
Pages (from-to)892-900
Number of pages9
JournalJournal of Bacteriology
Volume180
Issue number4
Publication statusPublished - 1998

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Cell Nucleus Division
Schizosaccharomyces
Cell Division
Mutation
Developmental Genes
Cytokinesis
Eukaryota
Mitosis
Alleles
Genes

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology

Cite this

Coordination of initiation of nuclear division and initiation of cell division in Schizosaccharomyces pombe : Genetic interactions of mutations. / Grallert, A.; Grallert, B.; Ribar, B.; Sipiczki, M.

In: Journal of Bacteriology, Vol. 180, No. 4, 1998, p. 892-900.

Research output: Contribution to journalArticle

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