Coordination of copper(II) ions to catechoyl-dipeptides, the inhibitors of leucine aminopeptidase and ribonucleotide reductase

Henryk Kozłowski, Barbara Radomska, T. Kiss, Jozsef Balla, Łucja Nakonieczna, Juliusz J. Pastuszak, Yves Langelier

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Potentiometric and spectroscopic study of the coordination ability of 2,3- and 3,4-dihydroxybenzoyl-dipeptides has shown that catechoyl-dipeptides are very strongly-binding ligands. The coordination begins at the catechol site at pH below 4. In the case of 2,3-dihydroxy derivatives the peptide unit may also be involved in the copper(II) ion coordination via its peptide nitrogens. The biological tests have indicated that the studied ligands may be effective inhibitors of ribonucleotide reductase in some cases, with a reasonable level of selectivity.

Original languageEnglish
Pages (from-to)779-787
Number of pages9
JournalJournal of Inorganic Biochemistry
Volume43
Issue number4
DOIs
Publication statusPublished - 1991

Fingerprint

Leucyl Aminopeptidase
Ribonucleotide Reductases
Dipeptides
Copper
Ions
Ligands
Peptides
Nitrogen
Derivatives
catechol

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Coordination of copper(II) ions to catechoyl-dipeptides, the inhibitors of leucine aminopeptidase and ribonucleotide reductase. / Kozłowski, Henryk; Radomska, Barbara; Kiss, T.; Balla, Jozsef; Nakonieczna, Łucja; Pastuszak, Juliusz J.; Langelier, Yves.

In: Journal of Inorganic Biochemistry, Vol. 43, No. 4, 1991, p. 779-787.

Research output: Contribution to journalArticle

Kozłowski, Henryk ; Radomska, Barbara ; Kiss, T. ; Balla, Jozsef ; Nakonieczna, Łucja ; Pastuszak, Juliusz J. ; Langelier, Yves. / Coordination of copper(II) ions to catechoyl-dipeptides, the inhibitors of leucine aminopeptidase and ribonucleotide reductase. In: Journal of Inorganic Biochemistry. 1991 ; Vol. 43, No. 4. pp. 779-787.
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