Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum

Ibolya Czegle, Simona Piccirella, Silvia Senesi, Miklós Csala, József Mandl, Gábor Bánhegyi, Rosella Fulceri, Angelo Benedetti

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

11β-Hydroxysteroid dehydrogenase type 1 (11βHSD1) is a NADP(H)-dependent oxidoreductase of the ER lumen, which may have an important role in the pathogenesis of metabolic syndrome. Here, the functional coupling of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase (H6PDH) was investigated in rat liver microsomal vesicles. The results demonstrate the existence of a separate intraluminal pyridine nucleotide pool in the hepatic endoplasmic reticulum and a close cooperation between 11βHSD1 and H6PDH based on their co-localization and the mutual generation of cofactors for each other.

Original languageEnglish
Pages (from-to)24-25
Number of pages2
JournalMolecular and Cellular Endocrinology
Volume248
Issue number1-2
DOIs
Publication statusPublished - Mar 27 2006

Keywords

  • 11β-Hydroxysteroid dehydrogenase type 1
  • Hexose-6-phosphate dehydrogenase
  • Pyridine nucleotides
  • Rat liver microsomes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Fingerprint Dive into the research topics of 'Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum'. Together they form a unique fingerprint.

  • Cite this