Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum

Ibolya Czegle, Simona Piccirella, Silvia Senesi, M. Csala, J. Mandl, G. Bánhegyi, Rosella Fulceri, Angelo Benedetti

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

11β-Hydroxysteroid dehydrogenase type 1 (11βHSD1) is a NADP(H)-dependent oxidoreductase of the ER lumen, which may have an important role in the pathogenesis of metabolic syndrome. Here, the functional coupling of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase (H6PDH) was investigated in rat liver microsomal vesicles. The results demonstrate the existence of a separate intraluminal pyridine nucleotide pool in the hepatic endoplasmic reticulum and a close cooperation between 11βHSD1 and H6PDH based on their co-localization and the mutual generation of cofactors for each other.

Original languageEnglish
Pages (from-to)24-25
Number of pages2
JournalMolecular and Cellular Endocrinology
Volume248
Issue number1-2
DOIs
Publication statusPublished - Mar 27 2006

Fingerprint

11-beta-Hydroxysteroid Dehydrogenases
Endoplasmic Reticulum
Nucleotides
Liver
NADP
Rats
Oxidoreductases
galactose-6-phosphate dehydrogenase
pyridine

Keywords

  • 11β-Hydroxysteroid dehydrogenase type 1
  • Hexose-6-phosphate dehydrogenase
  • Pyridine nucleotides
  • Rat liver microsomes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum. / Czegle, Ibolya; Piccirella, Simona; Senesi, Silvia; Csala, M.; Mandl, J.; Bánhegyi, G.; Fulceri, Rosella; Benedetti, Angelo.

In: Molecular and Cellular Endocrinology, Vol. 248, No. 1-2, 27.03.2006, p. 24-25.

Research output: Contribution to journalArticle

@article{448dd8f0f8e243f4a0bbf618d5a6e189,
title = "Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum",
abstract = "11β-Hydroxysteroid dehydrogenase type 1 (11βHSD1) is a NADP(H)-dependent oxidoreductase of the ER lumen, which may have an important role in the pathogenesis of metabolic syndrome. Here, the functional coupling of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase (H6PDH) was investigated in rat liver microsomal vesicles. The results demonstrate the existence of a separate intraluminal pyridine nucleotide pool in the hepatic endoplasmic reticulum and a close cooperation between 11βHSD1 and H6PDH based on their co-localization and the mutual generation of cofactors for each other.",
keywords = "11β-Hydroxysteroid dehydrogenase type 1, Hexose-6-phosphate dehydrogenase, Pyridine nucleotides, Rat liver microsomes",
author = "Ibolya Czegle and Simona Piccirella and Silvia Senesi and M. Csala and J. Mandl and G. B{\'a}nhegyi and Rosella Fulceri and Angelo Benedetti",
year = "2006",
month = "3",
day = "27",
doi = "10.1016/j.mce.2005.10.018",
language = "English",
volume = "248",
pages = "24--25",
journal = "Molecular and Cellular Endocrinology",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum

AU - Czegle, Ibolya

AU - Piccirella, Simona

AU - Senesi, Silvia

AU - Csala, M.

AU - Mandl, J.

AU - Bánhegyi, G.

AU - Fulceri, Rosella

AU - Benedetti, Angelo

PY - 2006/3/27

Y1 - 2006/3/27

N2 - 11β-Hydroxysteroid dehydrogenase type 1 (11βHSD1) is a NADP(H)-dependent oxidoreductase of the ER lumen, which may have an important role in the pathogenesis of metabolic syndrome. Here, the functional coupling of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase (H6PDH) was investigated in rat liver microsomal vesicles. The results demonstrate the existence of a separate intraluminal pyridine nucleotide pool in the hepatic endoplasmic reticulum and a close cooperation between 11βHSD1 and H6PDH based on their co-localization and the mutual generation of cofactors for each other.

AB - 11β-Hydroxysteroid dehydrogenase type 1 (11βHSD1) is a NADP(H)-dependent oxidoreductase of the ER lumen, which may have an important role in the pathogenesis of metabolic syndrome. Here, the functional coupling of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase (H6PDH) was investigated in rat liver microsomal vesicles. The results demonstrate the existence of a separate intraluminal pyridine nucleotide pool in the hepatic endoplasmic reticulum and a close cooperation between 11βHSD1 and H6PDH based on their co-localization and the mutual generation of cofactors for each other.

KW - 11β-Hydroxysteroid dehydrogenase type 1

KW - Hexose-6-phosphate dehydrogenase

KW - Pyridine nucleotides

KW - Rat liver microsomes

UR - http://www.scopus.com/inward/record.url?scp=33644906113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644906113&partnerID=8YFLogxK

U2 - 10.1016/j.mce.2005.10.018

DO - 10.1016/j.mce.2005.10.018

M3 - Article

C2 - 16337333

AN - SCOPUS:33644906113

VL - 248

SP - 24

EP - 25

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

IS - 1-2

ER -