Convergence of cortical and sensory driver inputs on single thalamocortical cells

Alexander Groh, Hajnalka Bokor, Rebecca A. Mease, Viktor M. Plattner, Balázs Hangya, Albrecht Stroh, Martin Deschenes, L. Acsády

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Ascending and descending information is relayed through the thalamus via strong, "driver" pathways. According to our current knowledge, different driver pathways are organized in parallel streams and do not interact at the thalamic level. Using an electron microscopic approach combined with optogenetics and in vivo physiology, we examined whether driver inputs arising from different sources can interact at single thalamocortical cells in the rodent somatosensory thalamus (nucleus posterior, POm). Both the anatomical and the physiological data demonstrated that ascending driver inputs from the brainstem and descending driver inputs from cortical layer 5 pyramidal neurons converge and interact on single thalamocortical neurons in POm. Both individual pathways displayed driver properties, but they interacted synergistically in a time-dependent manner and when co-activated, supralinearly increased the output of thalamus. As a consequence, thalamocortical neurons reported the relative timing between sensory events and ongoing cortical activity. We conclude that thalamocortical neurons can receive 2 powerful inputs of different origin, rather than only a single one as previously suggested. This allows thalamocortical neurons to integrate raw sensory information with powerful cortical signals and transfer the integrated activity back to cortical networks.

Original languageEnglish
Pages (from-to)3167-3179
Number of pages13
JournalCerebral Cortex
Volume24
Issue number12
DOIs
Publication statusPublished - Dec 1 2014

Fingerprint

Neurons
Thalamus
Posterior Thalamic Nuclei
Optogenetics
Pyramidal Cells
Brain Stem
Rodentia
Electrons

Keywords

  • Layer 5B
  • Posterior-medial nucleus
  • Relay
  • Somatosensory
  • Supralinear
  • Top-down processing
  • Trigeminal

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Medicine(all)

Cite this

Groh, A., Bokor, H., Mease, R. A., Plattner, V. M., Hangya, B., Stroh, A., ... Acsády, L. (2014). Convergence of cortical and sensory driver inputs on single thalamocortical cells. Cerebral Cortex, 24(12), 3167-3179. https://doi.org/10.1093/cercor/bht173

Convergence of cortical and sensory driver inputs on single thalamocortical cells. / Groh, Alexander; Bokor, Hajnalka; Mease, Rebecca A.; Plattner, Viktor M.; Hangya, Balázs; Stroh, Albrecht; Deschenes, Martin; Acsády, L.

In: Cerebral Cortex, Vol. 24, No. 12, 01.12.2014, p. 3167-3179.

Research output: Contribution to journalArticle

Groh, A, Bokor, H, Mease, RA, Plattner, VM, Hangya, B, Stroh, A, Deschenes, M & Acsády, L 2014, 'Convergence of cortical and sensory driver inputs on single thalamocortical cells', Cerebral Cortex, vol. 24, no. 12, pp. 3167-3179. https://doi.org/10.1093/cercor/bht173
Groh A, Bokor H, Mease RA, Plattner VM, Hangya B, Stroh A et al. Convergence of cortical and sensory driver inputs on single thalamocortical cells. Cerebral Cortex. 2014 Dec 1;24(12):3167-3179. https://doi.org/10.1093/cercor/bht173
Groh, Alexander ; Bokor, Hajnalka ; Mease, Rebecca A. ; Plattner, Viktor M. ; Hangya, Balázs ; Stroh, Albrecht ; Deschenes, Martin ; Acsády, L. / Convergence of cortical and sensory driver inputs on single thalamocortical cells. In: Cerebral Cortex. 2014 ; Vol. 24, No. 12. pp. 3167-3179.
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