Convergence chromatographic determination of camphor in the essential oil of Tanacetum parthenium L.

Krisztina Végh, Eszter Riethmüller, Anita Tóth, Ágnes Alberti, S. Béni, József Balla, A. Kéry

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Feverfew (Tanacetum parthenium L., Asteraceae) is a perennial medicinal plant which has been used to alleviate the symptoms of migraine, headache and rheumatoid arthritis and possesses numerous pharmacological activities. An ultra-high-performance supercritical fluid chromatographic method (UHPSFC) was developed and validated in accordance with the International Conference on Harmonization guidelines in order to determine the camphor content of the volatile oil, which was accurate, precise, robust and selective. The method was validated for specificity, accuracy (100.2%), repeatability and intermediate precision, linearity (r2 > 0.999), limit of detection (2.055 μg/mL), limit of quantification (6.228 μg/mL) and robustness. The common range of accuracy and linearity was between 0.125 and 1.000 mg/mL. Steam distillation was carried out in order to study the essential oil yield of three different T. parthenium L. samples originating from Hungarian medicinal herb collections. The camphor content of the essential oils from the aerial parts of feverfew samples from different origin was compared. Although the composition of the essential oil is well reported, a validated quantitative UHPSFC method for the determination of the constituents is presented herein for the first time.

Original languageEnglish
Pages (from-to)2031-2037
Number of pages7
JournalBiomedical Chromatography
Volume30
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

Fingerprint

Tanacetum parthenium
Camphor
Volatile Oils
Supercritical fluids
Medicinal Plants
Oil and Gas Fields
Asteraceae
Distillation
Steam
Migraine Disorders
Limit of Detection
Rheumatoid Arthritis
Pharmacology
Guidelines
Antennas
Chemical analysis

Keywords

  • camphor
  • convergence chromatography
  • method validation
  • Tanacetum parthenium L

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Convergence chromatographic determination of camphor in the essential oil of Tanacetum parthenium L. / Végh, Krisztina; Riethmüller, Eszter; Tóth, Anita; Alberti, Ágnes; Béni, S.; Balla, József; Kéry, A.

In: Biomedical Chromatography, Vol. 30, No. 12, 01.12.2016, p. 2031-2037.

Research output: Contribution to journalArticle

Végh, Krisztina ; Riethmüller, Eszter ; Tóth, Anita ; Alberti, Ágnes ; Béni, S. ; Balla, József ; Kéry, A. / Convergence chromatographic determination of camphor in the essential oil of Tanacetum parthenium L. In: Biomedical Chromatography. 2016 ; Vol. 30, No. 12. pp. 2031-2037.
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