Convenient synthesis of 2-substituted 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones

Eszter Kókai, József Nagy, Tünde Tóth, József Kupai, P. Huszthy, Gyula Simig, Balázs Volk

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A new synthetic route was elaborated at our laboratory providing a convenient access to 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones (diazaoxindoles), a compound family of biological relevance. Treatment of the easily available ethyl 2-(4-chloropyrimidin-5-yl)acetate derivatives with ammonia afforded the corresponding 2-(4-aminopyrimidin-5-yl)acetamides, which were finally cyclized to the target compounds.

Original languageEnglish
Pages (from-to)767-773
Number of pages7
JournalMonatshefte fur Chemie
Issue number4
Publication statusPublished - Apr 1 2016



  • Chlorination
  • Cyclization
  • Elimination
  • Heterocycles

ASJC Scopus subject areas

  • Chemistry(all)

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