Convenient syntheses of 1,2-trans selenoglycosides using isoselenuronium salts as glycosylselenenyl transfer reagents

Ambati Ashok Kumar, Tünde Zita Illyés, Katalin E. Kövér, László Szilágyi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Se-glycosyl-isoselenuronium salts such as three and four which can be prepared in one high-yielding step from acetohalogeno sugars proved to be convenient starting materials for the syntheses of a variety of selenoglycosides. Reaction with (ar)alkyl halides proceeds under mild conditions, in short time, at room temperature to afford the corresponding selenoglycosides in good yields. Aryl halides react to appreciable extent only if bearing activating nitro groups on the aromatic ring. Reactions with acylating reagents such as acetic anhydride and benzoyl chlorides furnished anomeric selenoesters some of which were recently proposed as starting compounds for alternative selenoglycoside syntheses. Selenodisaccharides with two different monosaccharide units could also be prepared via reactions of glycosyl-isoselenuronium salts with monosaccharide derivatives bearing primary or secondary triflate groups.

Original languageEnglish
Pages (from-to)8-18
Number of pages11
JournalCarbohydrate Research
Volume360
DOIs
Publication statusPublished - Oct 1 2012

Keywords

  • Glycosyl selenocarboxylates
  • Isoselenuronium salts
  • Odorless reagents
  • Selenodisaccharides
  • Selenoglycosides

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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