Convenient methods for the synthesis of d4, d2 and d6 isotopomers of 4-(4-fluorobenzyl)piperidine

Ágnes Proszenyák, B. Ágai, G. Tárkányi, László Vida, F. Faigl

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Pure 4-(4-fluoro-[2,3,5,6-2H4]benzyl)piperidine was prepared via the Grignard reaction of 4-fluoro-[2,3,5,6-2H 4]bromobenzene and pyridine-4-aldehyde followed by consecutive deoxygenation and heteroatomic ring saturation in the presence of palladium on carbon catalyst. An improved method for the catalytic H/D exchange in benzylic positions of 4-(4-fluorobenzyl)piperidine and its d4 derivative has also been described.

Original languageEnglish
Pages (from-to)421-427
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume48
Issue number6
DOIs
Publication statusPublished - May 2005

Fingerprint

Palladium
Aldehydes
Carbon
Derivatives
Catalysts
piperidine
pyridine
bromobenzene

Keywords

  • Benzylpiperidines
  • Catalytic hydrogenation
  • Deuterium-labelled compounds
  • Grignard reaction
  • Palladium on carbon

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology

Cite this

Convenient methods for the synthesis of d4, d2 and d6 isotopomers of 4-(4-fluorobenzyl)piperidine. / Proszenyák, Ágnes; Ágai, B.; Tárkányi, G.; Vida, László; Faigl, F.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 48, No. 6, 05.2005, p. 421-427.

Research output: Contribution to journalArticle

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AU - Proszenyák, Ágnes

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AU - Tárkányi, G.

AU - Vida, László

AU - Faigl, F.

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