Convenient methods for the synthesis of d4, d2 and d6 isotopomers of 4-(4-fluorobenzyl)piperidine

Ágnes Proszenyák, Béla Ágai, Gábor Tárkányi, László Vida, Ferenc Faigl

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Pure 4-(4-fluoro-[2,3,5,6-2H4]benzyl)piperidine was prepared via the Grignard reaction of 4-fluoro-[2,3,5,6-2H 4]bromobenzene and pyridine-4-aldehyde followed by consecutive deoxygenation and heteroatomic ring saturation in the presence of palladium on carbon catalyst. An improved method for the catalytic H/D exchange in benzylic positions of 4-(4-fluorobenzyl)piperidine and its d4 derivative has also been described.

Original languageEnglish
Pages (from-to)421-427
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume48
Issue number6
DOIs
Publication statusPublished - May 1 2005

Keywords

  • Benzylpiperidines
  • Catalytic hydrogenation
  • Deuterium-labelled compounds
  • Grignard reaction
  • Palladium on carbon

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Convenient methods for the synthesis of d<sub>4</sub>, d<sub>2</sub> and d<sub>6</sub> isotopomers of 4-(4-fluorobenzyl)piperidine'. Together they form a unique fingerprint.

  • Cite this