Controlling the Physical Stability of Liposomal Colloids

Ferenc Csempesz, István Puskás

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Uncharged homopolymers such as poly(vinyl alcohol), polyvinylpyrrolidone (PVP) and methylcellulose were used for the stabilization of small unilamellar vesicles in aqueous media of various composition. Polymer-free and polymer-bearing liposomes from dimyristoylphosphatidylcholine and dipalmitoylphosphatidylcholine were prepared under standardized conditions. Sterically stabilized liposomes were formed by incorporating dissolved macromolecules in the membrane bilayer of vesicles. The stability of liposomal dispersions, at physiological pH values and in the presence of natural cyclodextrins (CDs), were studied. The physical stability of vesicles was tested by measuring the size distribution of liposomes by means of a Malvern Zetasizer 4 apparatus. It was shown that most of the polymers are efficient steric stabilizers for the vesicles. PVP of high molecular mass exhibited the most efficient stabilizing effect at each pH studied, indicating that the formation of a relatively thick polymer layer around the lipid bilayers ensures enhanced and prolonged physical stability of liposomes. Also, the polymers proved to be suitable for preventing the destruction of phospholipid bilayers that dissolved natural CDs cause. Using these macromolecules, vesicle stability and interactions in dispersions of liposomal colloids can be well controlled.

Original languageEnglish
Title of host publicationColloid Stability and Application in Pharmacy
PublisherWiley-VCH
Pages79-89
Number of pages11
Volume3
ISBN (Print)9783527314638
DOIs
Publication statusPublished - Jan 20 2011

Keywords

  • Liposomal colloids
  • Physical stability

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Csempesz, F., & Puskás, I. (2011). Controlling the Physical Stability of Liposomal Colloids. In Colloid Stability and Application in Pharmacy (Vol. 3, pp. 79-89). Wiley-VCH. https://doi.org/10.1002/9783527631117.ch3