Controlling ionic current through a nanopore by tuning pH: a local equilibrium Monte Carlo study

Dávid Fertig, Mónika Valiskó, Dezső Boda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The purpose of this work is to create a model of a nanofluidic transistor which is able to mimic the effects of pH on nanopore conductance. The pH of the electrolyte is an experimentally controllable parameter through which the charge pattern can be tuned: pH affects the ratio of the protonated/deprotonated forms of the functional groups anchored to the surface of the nanopore (for example, amino and carboxyl groups). Thus, the behaviour of the bipolar transistor changes as it becomes ion selective in acidic/basic environments. We relate the surface charge to pH and perform particle simulations (Local Equilibrium Monte Carlo) with different nanopore geometries (cylindrical and double conical). The simulations form a self consistent system with the Nernst–Planck equation with which we compute ionic flux. We discuss the mechanism behind pH-control of ionic current: formation of depletion zones.

Original languageEnglish
Pages (from-to)2793-2801
Number of pages9
JournalMolecular Physics
Volume117
Issue number20
DOIs
Publication statusPublished - Oct 18 2019

Keywords

  • Monte Carlo
  • Nanopores
  • Nernst–Planck
  • pH
  • transistor

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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