Controlled technology for forming a nanostructured polymer coating for solid pharmaceuticals

István Csontos, Krisztián Rónaszegi, A. Szabó, S. Keszei, P. Anna, Pál Fekete, G. Marosi, Tibor Nagy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Simple method is proposed for in situ formation of nanodispersion through computer-controlled emulsion polymerization. The method is based on the application of cationic emulsifier during polymerization, which performs cation exchange with the surface Na ions of montmorillonite nanoparticles. The endpoint of polymerization is detected by Raman microscopy while the structure is determined by atomic force microscopy. The nanodispersion is used in the tablet-coating process. Raman microscopy provides a new non-destructive way for controlling the thickness and uniformity of the coatings during the procedure, while the surface defects can be determined by atomic force microscopy.

Original languageEnglish
Pages (from-to)884-888
Number of pages5
JournalPolymers for Advanced Technologies
Volume17
Issue number11-12
DOIs
Publication statusPublished - Nov 2006

Fingerprint

Drug products
Atomic force microscopy
Microscopic examination
Polymers
Polymerization
Bentonite
Coatings
Emulsion polymerization
Surface defects
Clay minerals
Pharmaceutical Preparations
Tablets
Cations
Ion exchange
Positive ions
Ions
Nanoparticles

Keywords

  • Atomic force microscopy (AFM)
  • Drug delivery systems
  • Emulsion polymerization
  • Nanocomposites
  • Raman microscopy

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

Controlled technology for forming a nanostructured polymer coating for solid pharmaceuticals. / Csontos, István; Rónaszegi, Krisztián; Szabó, A.; Keszei, S.; Anna, P.; Fekete, Pál; Marosi, G.; Nagy, Tibor.

In: Polymers for Advanced Technologies, Vol. 17, No. 11-12, 11.2006, p. 884-888.

Research output: Contribution to journalArticle

Csontos, István ; Rónaszegi, Krisztián ; Szabó, A. ; Keszei, S. ; Anna, P. ; Fekete, Pál ; Marosi, G. ; Nagy, Tibor. / Controlled technology for forming a nanostructured polymer coating for solid pharmaceuticals. In: Polymers for Advanced Technologies. 2006 ; Vol. 17, No. 11-12. pp. 884-888.
@article{b8f7bd8af56b4cb984fe9c1fe0db4bc8,
title = "Controlled technology for forming a nanostructured polymer coating for solid pharmaceuticals",
abstract = "Simple method is proposed for in situ formation of nanodispersion through computer-controlled emulsion polymerization. The method is based on the application of cationic emulsifier during polymerization, which performs cation exchange with the surface Na ions of montmorillonite nanoparticles. The endpoint of polymerization is detected by Raman microscopy while the structure is determined by atomic force microscopy. The nanodispersion is used in the tablet-coating process. Raman microscopy provides a new non-destructive way for controlling the thickness and uniformity of the coatings during the procedure, while the surface defects can be determined by atomic force microscopy.",
keywords = "Atomic force microscopy (AFM), Drug delivery systems, Emulsion polymerization, Nanocomposites, Raman microscopy",
author = "Istv{\'a}n Csontos and Kriszti{\'a}n R{\'o}naszegi and A. Szab{\'o} and S. Keszei and P. Anna and P{\'a}l Fekete and G. Marosi and Tibor Nagy",
year = "2006",
month = "11",
doi = "10.1002/pat.773",
language = "English",
volume = "17",
pages = "884--888",
journal = "Polymers for Advanced Technologies",
issn = "1042-7147",
publisher = "John Wiley and Sons Ltd",
number = "11-12",

}

TY - JOUR

T1 - Controlled technology for forming a nanostructured polymer coating for solid pharmaceuticals

AU - Csontos, István

AU - Rónaszegi, Krisztián

AU - Szabó, A.

AU - Keszei, S.

AU - Anna, P.

AU - Fekete, Pál

AU - Marosi, G.

AU - Nagy, Tibor

PY - 2006/11

Y1 - 2006/11

N2 - Simple method is proposed for in situ formation of nanodispersion through computer-controlled emulsion polymerization. The method is based on the application of cationic emulsifier during polymerization, which performs cation exchange with the surface Na ions of montmorillonite nanoparticles. The endpoint of polymerization is detected by Raman microscopy while the structure is determined by atomic force microscopy. The nanodispersion is used in the tablet-coating process. Raman microscopy provides a new non-destructive way for controlling the thickness and uniformity of the coatings during the procedure, while the surface defects can be determined by atomic force microscopy.

AB - Simple method is proposed for in situ formation of nanodispersion through computer-controlled emulsion polymerization. The method is based on the application of cationic emulsifier during polymerization, which performs cation exchange with the surface Na ions of montmorillonite nanoparticles. The endpoint of polymerization is detected by Raman microscopy while the structure is determined by atomic force microscopy. The nanodispersion is used in the tablet-coating process. Raman microscopy provides a new non-destructive way for controlling the thickness and uniformity of the coatings during the procedure, while the surface defects can be determined by atomic force microscopy.

KW - Atomic force microscopy (AFM)

KW - Drug delivery systems

KW - Emulsion polymerization

KW - Nanocomposites

KW - Raman microscopy

UR - http://www.scopus.com/inward/record.url?scp=33846373414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846373414&partnerID=8YFLogxK

U2 - 10.1002/pat.773

DO - 10.1002/pat.773

M3 - Article

AN - SCOPUS:33846373414

VL - 17

SP - 884

EP - 888

JO - Polymers for Advanced Technologies

JF - Polymers for Advanced Technologies

SN - 1042-7147

IS - 11-12

ER -