Controlled drug release on amine functionalized spherical MCM-41

A. Szegedi, Margarita Popova, Ivan Goshev, Szilvia Klébert, J. Mihály

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

MCM-41 silica with spherical morphology and small particle sizes (100 nm) was synthesized and modified by post-synthesis method with different amounts of 3-aminopropyltriethoxysilane (APTES). A comparative study of the adsorption and release of a model drug, ibuprofen, was carried out. The modified and drug loaded mesoporous materials were characterized by XRD, TEM, N 2 physisorption, elemental analysis, thermal analysis and FT-IR spectroscopy. A new method was developed for the quantitative determination of amino groups in surface modified mesoporous materials by the ninhydrin reaction. Good correlation was found between the amino content of the MCM-41 materials determined by the ninhydrin method and their ibuprofen adsorption capacity. Amino modification resulted in high degree of ibuprofen loading and slow release rate in comparison to the parent non-modified MCM-41.

Original languageEnglish
Pages (from-to)257-263
Number of pages7
JournalJournal of Solid State Chemistry
Volume194
DOIs
Publication statusPublished - Oct 2012

Fingerprint

Ibuprofen
Multicarrier modulation
Ninhydrin
Amines
amines
drugs
Mesoporous materials
adsorption
Pharmaceutical Preparations
Adsorption
thermal analysis
Physisorption
silicon dioxide
Silicon Dioxide
Thermoanalysis
transmission electron microscopy
Infrared spectroscopy
synthesis
Particle size
Silica

Keywords

  • Amino functionalization
  • Ibuprofen release
  • MCM-41
  • Ninhydrin reaction
  • Spherical particles

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry

Cite this

Controlled drug release on amine functionalized spherical MCM-41. / Szegedi, A.; Popova, Margarita; Goshev, Ivan; Klébert, Szilvia; Mihály, J.

In: Journal of Solid State Chemistry, Vol. 194, 10.2012, p. 257-263.

Research output: Contribution to journalArticle

Szegedi, A. ; Popova, Margarita ; Goshev, Ivan ; Klébert, Szilvia ; Mihály, J. / Controlled drug release on amine functionalized spherical MCM-41. In: Journal of Solid State Chemistry. 2012 ; Vol. 194. pp. 257-263.
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