Controlled clustering of carboxylated SPIONs through polyethylenimine

Dániel Nesztor, Krisztina Bali, Ildikó Y. Tóth, Márta Szekeres, Etelka Tombácz

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Clusters of magnetite nanoparticles (MNPs) were synthesized using poly(acrylic acid-co-maleic acid) coated MNPs (PAM@MNP) and branched polyethylenimine (PEI). Materials were characterized by potentiometric titration, zeta potential and dynamic light scattering (DLS) measurements. PEI and PAM@MNP are oppositely charged as characterized by zeta potential measurements (+8, -34 mV respectively) and titration (10.30 mmol -NH3 +/g PEI; 0.175 mmol -COO-/g PAM@MNP) at pH 6.5±0.2; therefore magnetic clusters are formed by electrostatic adhesion. Two different preparation methods and the effect of PEI and electrolyte (NaCl) concentration on the cluster formation was studied. Choosing an optimal concentration of PEI (charge ratio of PEI to PAM@MNP: 0.17) and electrolyte (10 mM), a concentrated (10 g MNP/L) product containing PEI-PAM@MNP nanoclusters with size of 165±10 nm was prepared. Its specific absorption rate (SAR) measured in AC magnetic field (110 kHz, 25 mT) is 12 W/g Fe. The clustered product is expected to have enhanced contrast efficiency in MRI.

Original languageEnglish
Pages (from-to)144-149
Number of pages6
JournalJournal of Magnetism and Magnetic Materials
Volume380
DOIs
Publication statusPublished - Apr 15 2015

Keywords

  • Carboxylated SPION
  • Hyperthermia
  • Magnetic cluster
  • Magnetic fluid
  • Specific absorption rate
  • Superparamagnetic iron oxide nanoparticle

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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