Control of prolactin secretion by excitatory amino acids

György M. Nagy, I. Bodnár, Zsuzsanna Bánky, B. Halász

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

This article provides an overview of the increasing number of observations indicating that excitatory amino acids are involved in the control of prolactin secretion. The information available suggests that these amino acids exert a stimulatory action on hypophysial prolactin. Administration of a glutamate receptor agonist induces significant increase in prolactin release in rats, monkeys, and rams. In contrast, noncompetitive antagonists of N-methyl-D-aspartate receptors decrease plasma levels and attenuate the preovulatory surge of prolactin. It appears that the endogenous glutamatergic system participates not only in the regulation of basal secretion of prolactin, but also in the control of physiological prolactin responses induced by the suckling stimulus or by stress. Recent findings suggest that the glutamatergic innervation of the hypothalamic paraventricular nucleus is involved in the mediation of the neural signal of the suckling stimulus-induced prolactin release as well as in the mediation of the stress-induced release of prolactin.

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalEndocrine
Volume28
Issue number3
DOIs
Publication statusPublished - Dec 2005

Fingerprint

Excitatory Amino Acids
Prolactin
Excitatory Amino Acid Agonists
Paraventricular Hypothalamic Nucleus
Glutamate Receptors
N-Methyl-D-Aspartate Receptors
Haplorhini
Amino Acids

Keywords

  • Excitatory amino acids
  • Glutamate
  • Paraventricular nucleus
  • Prolactin
  • Stress
  • Suckling stimulus

ASJC Scopus subject areas

  • Endocrinology

Cite this

Control of prolactin secretion by excitatory amino acids. / Nagy, György M.; Bodnár, I.; Bánky, Zsuzsanna; Halász, B.

In: Endocrine, Vol. 28, No. 3, 12.2005, p. 303-308.

Research output: Contribution to journalArticle

Nagy, György M. ; Bodnár, I. ; Bánky, Zsuzsanna ; Halász, B. / Control of prolactin secretion by excitatory amino acids. In: Endocrine. 2005 ; Vol. 28, No. 3. pp. 303-308.
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