Control of Metabolism by Dynamic Macromolecular Interactions

T. Keleti, J. OvÁdi

Research output: Chapter in Book/Report/Conference proceedingChapter

41 Citations (Scopus)

Abstract

This chapter discusses the control of metabolism by dynamic macromolecular interactions. Metabolic pathways are controlled and directed by pacemaker, bottleneck, and key enzymes. In general, no single enzyme is responsible for the control of a whole metabolic pathway. In pursuing the pacemaker theory, attempts are made to quantify metabolic regulation, and one studies each enzyme in a sequence separately in situ, determines its kinetic properties in the greatest possible detail and accuracy, and then seeks to determine how it works when it is in the intact cell. In prokaryotes and in eukaryotes the largest macrocompartment is the cytoplasm, containing quantities of soluble enzymes and is full of membranes associated with a great variety of organelles. A theoretical analysis of glycolysis in human erythrocytes has been provided, implicitly assuming that it proceeds in a homogeneous bulk solution without any interaction among the participating enzymes.

Original languageEnglish
Title of host publicationCurrent Topics in Cellular Regulation
Pages1-33
Number of pages33
EditionC
DOIs
Publication statusPublished - Jan 1 1988

Publication series

NameCurrent Topics in Cellular Regulation
NumberC
Volume29
ISSN (Print)0070-2137

ASJC Scopus subject areas

  • Cell Biology

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  • Cite this

    Keleti, T., & OvÁdi, J. (1988). Control of Metabolism by Dynamic Macromolecular Interactions. In Current Topics in Cellular Regulation (C ed., pp. 1-33). (Current Topics in Cellular Regulation; Vol. 29, No. C). https://doi.org/10.1016/B978-0-12-152829-4.50003-3