Translated title of the contribution: Contributions to the immunopathology of cutaneous and hepatic porphyria

E. Szabo, F. Czako, S. Husz

Research output: Contribution to journalArticle

1 Citation (Scopus)


In the case of 19 patients with porphyria cutanea tarda, biochemical and immunoserologic analysis, as well as immunofluorescence examination of biopsied liver tissue of 10 patients was carried out. While in rats suffering from expressed ingestive chemical injuries after HCB poisoning direct damage of onnective tissue septa with large amounts of reticular fibers prevails, this phenomenon could be observed only slightly in patients with porphyria cutanea tarda. In these patients specific autoantibody formation predominated against parenchymal cells of the gastrointestinal tract. In 4 of the cases slight, and in 1 marked tissue immunoglobulin binding could be demonstrated by immunofluorescence method around liver sinuses, bile canaliculi and hepatocytes. These findings raise the hypothesis that sometimes an immune mechanism can play a part in the progression of a porphyric liver lesion manifesting itself in fibrosis of varying degree.

Translated title of the contributionContributions to the immunopathology of cutaneous and hepatic porphyria
Original languageGerman
Pages (from-to)608-618
Number of pages11
JournalDermatologische Monatsschrift
Issue number6
Publication statusPublished - Dec 1 1973

ASJC Scopus subject areas

  • Dermatology

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