Contribution to physiological properties of poly(N-vinylpyrrolidone-alt-maleic acid), toxicity and hemagglutination tests

M. Azori, Z. Veres, G. Denes, F. Tudos

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Polyanions are among the few synthetic polymers that exhibit therapeutic activity on their own. Polyanions show a broad spectrum of activities as inhibitors of several types of tumors, viruses, bacteria, and other infective agents. The chemical synthesis and physico-chemical characterization of poly(N-vinylpyrrolidone-alt-maleic acid) have been carried out in our laboratories. In this paper, the acute toxicity of this copolymer is examined by two routes of parenteral administration. The effect of prolonged daily treatment of animals, (14-day toxicity), the results of hemagglutination tests of the original, and the modified copolymer as polymer drug models are discussed.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalJournal of Bioactive and Compatible Polymers
Volume5
Issue number3
Publication statusPublished - Jul 1990

Fingerprint

Hemagglutination Tests
Toxicity Tests
Toxicity
Polymers
Copolymers
Oncogenic Viruses
Acids
Viruses
Tumors
Bacteria
Animals
Pharmaceutical Preparations
maleic acid
N-vinyl-2-pyrrolidinone
polyanions
Therapeutics

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Contribution to physiological properties of poly(N-vinylpyrrolidone-alt-maleic acid), toxicity and hemagglutination tests. / Azori, M.; Veres, Z.; Denes, G.; Tudos, F.

In: Journal of Bioactive and Compatible Polymers, Vol. 5, No. 3, 07.1990, p. 305-309.

Research output: Contribution to journalArticle

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