Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity

J. Kiss, D. Muller

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

The neural cell adhesion molecule (NCAM) and its polysialylated form PSA-NCAM contribute to many aspects of the development and plasticity of the central nervous system. This includes mechanisms of cell differentiation and migration, neurite outgrowth, establishment of specific patterns of synaptic connections, synaptic plasticity and long-term potentiation. How NCAM and PSA-NCAM contribute to regulate all these different mechanisms remains essentially unknown. Adhesive properties appear to be important, but recent studies also point to possible interactions between NCAM and PSA-NCAM with intracellular signalling cascades that are essential to biological functions. Some of these mechanisms are discussed and a hypothesis is proposed based on the existence of cross-talk between these molecules and signalling pathways mediated by growth factors.

Original languageEnglish
Pages (from-to)297-310
Number of pages14
JournalReviews in the Neurosciences
Volume12
Issue number4
Publication statusPublished - 2001

Fingerprint

Neural Cell Adhesion Molecules
Neuronal Plasticity
Long-Term Potentiation
Adhesives
Cell Movement
Cell Differentiation
Intercellular Signaling Peptides and Proteins
Central Nervous System

Keywords

  • Cell adhesion
  • Central nervous system
  • Plasticity
  • Signalling

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity. / Kiss, J.; Muller, D.

In: Reviews in the Neurosciences, Vol. 12, No. 4, 2001, p. 297-310.

Research output: Contribution to journalArticle

@article{d28809708745444dbb52d2768e3c21e0,
title = "Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity",
abstract = "The neural cell adhesion molecule (NCAM) and its polysialylated form PSA-NCAM contribute to many aspects of the development and plasticity of the central nervous system. This includes mechanisms of cell differentiation and migration, neurite outgrowth, establishment of specific patterns of synaptic connections, synaptic plasticity and long-term potentiation. How NCAM and PSA-NCAM contribute to regulate all these different mechanisms remains essentially unknown. Adhesive properties appear to be important, but recent studies also point to possible interactions between NCAM and PSA-NCAM with intracellular signalling cascades that are essential to biological functions. Some of these mechanisms are discussed and a hypothesis is proposed based on the existence of cross-talk between these molecules and signalling pathways mediated by growth factors.",
keywords = "Cell adhesion, Central nervous system, Plasticity, Signalling",
author = "J. Kiss and D. Muller",
year = "2001",
language = "English",
volume = "12",
pages = "297--310",
journal = "Neural Plasticity",
issn = "2090-5904",
publisher = "Hindawi Publishing Corporation",
number = "4",

}

TY - JOUR

T1 - Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity

AU - Kiss, J.

AU - Muller, D.

PY - 2001

Y1 - 2001

N2 - The neural cell adhesion molecule (NCAM) and its polysialylated form PSA-NCAM contribute to many aspects of the development and plasticity of the central nervous system. This includes mechanisms of cell differentiation and migration, neurite outgrowth, establishment of specific patterns of synaptic connections, synaptic plasticity and long-term potentiation. How NCAM and PSA-NCAM contribute to regulate all these different mechanisms remains essentially unknown. Adhesive properties appear to be important, but recent studies also point to possible interactions between NCAM and PSA-NCAM with intracellular signalling cascades that are essential to biological functions. Some of these mechanisms are discussed and a hypothesis is proposed based on the existence of cross-talk between these molecules and signalling pathways mediated by growth factors.

AB - The neural cell adhesion molecule (NCAM) and its polysialylated form PSA-NCAM contribute to many aspects of the development and plasticity of the central nervous system. This includes mechanisms of cell differentiation and migration, neurite outgrowth, establishment of specific patterns of synaptic connections, synaptic plasticity and long-term potentiation. How NCAM and PSA-NCAM contribute to regulate all these different mechanisms remains essentially unknown. Adhesive properties appear to be important, but recent studies also point to possible interactions between NCAM and PSA-NCAM with intracellular signalling cascades that are essential to biological functions. Some of these mechanisms are discussed and a hypothesis is proposed based on the existence of cross-talk between these molecules and signalling pathways mediated by growth factors.

KW - Cell adhesion

KW - Central nervous system

KW - Plasticity

KW - Signalling

UR - http://www.scopus.com/inward/record.url?scp=0035215303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035215303&partnerID=8YFLogxK

M3 - Article

C2 - 11783716

AN - SCOPUS:0035215303

VL - 12

SP - 297

EP - 310

JO - Neural Plasticity

JF - Neural Plasticity

SN - 2090-5904

IS - 4

ER -