Contribution of the heme oxygenase pathway to the maintenance of the hypothalamic blood flow during diminished nitric oxide synthesis

Béla Horváth, András Hrabák, Krisztina Káldi, Péter Sándor, Zoltán Benyó

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15 Citations (Scopus)

Abstract

The cerebrovascular effects of the heme oxygenase-carbon monoxide pathway were studied in the rat hypothalamus. Intraperitoneal administration of the heme oxygenase inhibitor zinc deuteroporphyrin 2,4-bis glycol (ZnDPBG, 45 μmol/kg) had no significant effect on the resting cerebral blood flow, but increased hypothalamic nitric oxide synthase activity by 67% without changing the CSF cyclic GMP concentration. After pharmacologic inhibition of nitric oxide synthase, the diminished cerebral blood flow was further reduced by 22% after administration of ZnDPBG, and the effect showed direct correlation with the baseline perfusion level. Therefore, endogenous carbon monoxide may significantly contribute to the cerebral vasoregulation under resting conditions and in pathophysiologic states associated with diminished nitric oxide synthesis.

Original languageEnglish
Pages (from-to)653-657
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume23
Issue number6
DOIs
Publication statusPublished - Jun 1 2003

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Keywords

  • Endothelial dysfunction
  • Heme oxygenase
  • Hypothalamus
  • Nitric oxide synthase

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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