Contribution of differently localized α2- and β-adrenoceptors in the modulation of TNF-α and IL-10 production in endotoxemic mice

J. Szelényi, J. P. Kiss, É Puskás, M. Szelényi, E. S. Vizi

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Abstract

Evidence is presented that the immune response to endotoxemia is under tonic control of the sympathetic nervous system. Adrenergic agents may influence the immune response both directly through α- and β-adrenergic receptors expressed by immunologically competent cells and indirectly via alteration of the endogenous NA level by influencing the activity of release-regulating presynaptic α2-adrenoceptors located on the sympathetic nerve terminals. In the immunomodulatory effect of NA/adrenergic drugs, their action on β-adrenoceptors was dominant, but the considerable role of α-adrenoceptors on macrophages was also demonstrated. According to our findings, regulation of the ascending wing of the inflammatory response, that is, TNF-α production, is more sensitive to the adrenoceptor effect, whereas modulation of its deregulation by IL-10 production also involves some other determining factors.

Original languageEnglish
Pages (from-to)145-153
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume917
Publication statusPublished - Jan 1 2000

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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