Contrast agents for magnetic resonance spectroscopy: A method to obtain increased information in in vivo and in vitro spectroscopy

H. M. Swartz, K. Chen, H. Hu, K. Hideg

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The concept of contrast, which now is an integral part of many magnetic resonance imaging studies, can be extended successfully to magnetic resonance spectroscopy. It involves the use of paramagnetic molecules whose distribution is restricted in some manner, thereby causing differential effects on the NMR spectra. As an illustrative example, the effects of lipophilic nitroxide stable free radicals on the NMR spectra of serum and lipoproteins are shown. These nitroxides differentially broaden away components of the spectra due to the nuclei of methylene and methyl groups, which enables the usually obscured peaks of lactate to be observed fully. The concept can be applied to differential distribution of the contrast agent on the basis of solubility, charge, and/or compartmentalization. It can be used with any type of NMR spectroscopy and any type of paramagnetic contrast (broadening) agent.

Original languageEnglish
Pages (from-to)372-377
Number of pages6
JournalMagnetic Resonance in Medicine
Volume22
Issue number2
Publication statusPublished - 1991

Fingerprint

Contrast Media
Spectrum Analysis
Magnetic Resonance Spectroscopy
Solubility
Lipoproteins
Free Radicals
Lactic Acid
Magnetic Resonance Imaging
Serum
In Vitro Techniques

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Contrast agents for magnetic resonance spectroscopy : A method to obtain increased information in in vivo and in vitro spectroscopy. / Swartz, H. M.; Chen, K.; Hu, H.; Hideg, K.

In: Magnetic Resonance in Medicine, Vol. 22, No. 2, 1991, p. 372-377.

Research output: Contribution to journalArticle

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